| IED ID | IndEnz0002004060 |
| Enzyme Type ID | protease004060 |
| Protein Name |
Putative cysteine proteinase CG12163 EC 3.4.22.- |
| Gene Name | CG12163 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MRLFAAATVALVLLLGQAAGEELAEERAGQAQGDAESTESSETTTDQAVSEPPITLVHVLNPGEREYLSPNLIGVQNIAMTFLPLSMNFVNIIDAFREITAGVRYEILLNALDTKAIQPAEADIVCRLVILEKPWLRTQWGDKHRELVTSNCTDPAVNSVAGDPAEKARLLNEKYVHRSRRSANDILGRHKPYDEEAAKAQLQKSLDKLTAGEGPHYKIVKVYSASRQVDSGILTRIDADLIDGSEEQHRCIVDIWTKVWVRKDEHEITFKCRNQPVVQARHTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAVLA |
| Enzyme Length | 614 |
| Uniprot Accession Number | Q9VN93 |
| Absorption | |
| Active Site | ACT_SITE 418; /evidence=ECO:0000250; ACT_SITE 555; /evidence=ECO:0000250; ACT_SITE 581; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: May have a role in autophagic cell death. {ECO:0000303|PubMed:12593804}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Compositional bias (1); Disulfide bond (3); Glycosylation (3); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Alternative splicing;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11116097; 12865422; 13130081; 17194782; 17285308; 18067683; 18355804; 20107052; 20220848; 20371351; 20730086; 20739554; 21074052; 21447707; 21480662; 23071443; 23617951; 25294943; 25294944; 25634895; 25776889; 25848931; 26063572; 26290570; 26512413; 26801178; 27582081; 29066546; 29452635; 31068592; 31722958; 33112206; |
| Motif | |
| Gene Encoded By | |
| Mass | 68,961 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |