| IED ID |
IndEnz0002004065 |
| Enzyme Type ID |
protease004065 |
| Protein Name |
Protease inhibitor Egf1.0
|
| Gene Name |
O12 |
| Organism |
Microplitis demolitor bracovirus (isolate Webb) (MdBV) |
| Taxonomic Lineage |
Viruses
Polydnaviridae
Bracovirus
Microplitis demolitor bracovirus (MdBV)
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
|
| Enzyme Sequence |
MYIDTGIMSNNIFLFAFFALVGLTRIEAMPTKGSEGTWDVDYEDQEHTGITCRENEHYNSTRIECEEECNDRNNKLCYRFQQFCWCNEGYIRNSSHICVKLEDCLKDEEQKSETLASSANNDSSKRLEDDLKLFSHDSVSHTSLEPETQAQKFNGIIDQETLDLVFGKPENSWAENKPLETKTQAQKFNGKIDQETLDLVFGKPKNSSAEKKPLETETQAQKFNGIIDQETLD |
| Enzyme Length |
233 |
| Uniprot Accession Number |
Q4ZJY8 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Counteracts the host humoral immune response by inhibiting the processing and the amidolytic activity of host PAP3. Thereby, melanization of host hemolymph, normally producing several reactive intermediates toxic for viruses, is deregulated and proper immune response cannot occur. {ECO:0000269|PubMed:18032603}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Domain (1); Mutagenesis (1); Region (1); Signal peptide (1) |
| Keywords |
Host-virus interaction;Inhibition of host innate immune response by virus;Reference proteome;Signal;Viral immunoevasion |
| Interact With |
|
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..28; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
26,734 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|