IED ID | IndEnz0002004136 |
Enzyme Type ID | protease004136 |
Protein Name |
Proteinase inhibitor Aprin |
Gene Name | inh aprI PA1250 |
Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Enzyme Sequence | MSASAKLSRMVCLLCGFFSTGISMASSLILLSASDLAGQWTLQQDEAPAICHLELRDSEVAEASGYDLGGDTACLTRWLPSEPRAWRPTPAGIALLERGGLTLMLLGRQGEGDYRVQKGDGGQLVLRRATP |
Enzyme Length | 131 |
Uniprot Accession Number | Q03026 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity). {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Beta strand (11); Chain (1); Disulfide bond (1); Helix (2); Signal peptide (1); Turn (1) |
Keywords | 3D-structure;Disulfide bond;Metalloenzyme inhibitor;Metalloprotease inhibitor;Periplasm;Protease inhibitor;Reference proteome;Signal |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Periplasm. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..26; /evidence=ECO:0000250 |
Structure 3D | NMR spectroscopy (1); X-ray crystallography (1) |
Cross Reference PDB | 1JIW; 2RN4; |
Mapped Pubmed ID | 15803404; 18214691; |
Motif | |
Gene Encoded By | |
Mass | 13,980 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |