Detail Information for IndEnz0002004136
IED ID IndEnz0002004136
Enzyme Type ID protease004136
Protein Name Proteinase inhibitor
Aprin
Gene Name inh aprI PA1250
Organism Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Enzyme Sequence MSASAKLSRMVCLLCGFFSTGISMASSLILLSASDLAGQWTLQQDEAPAICHLELRDSEVAEASGYDLGGDTACLTRWLPSEPRAWRPTPAGIALLERGGLTLMLLGRQGEGDYRVQKGDGGQLVLRRATP
Enzyme Length 131
Uniprot Accession Number Q03026
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (11); Chain (1); Disulfide bond (1); Helix (2); Signal peptide (1); Turn (1)
Keywords 3D-structure;Disulfide bond;Metalloenzyme inhibitor;Metalloprotease inhibitor;Periplasm;Protease inhibitor;Reference proteome;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Periplasm.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..26; /evidence=ECO:0000250
Structure 3D NMR spectroscopy (1); X-ray crystallography (1)
Cross Reference PDB 1JIW; 2RN4;
Mapped Pubmed ID 15803404; 18214691;
Motif
Gene Encoded By
Mass 13,980
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda