| IED ID | IndEnz0002004144 |
| Enzyme Type ID | protease004144 |
| Protein Name |
Kallikrein-11 hK11 EC 3.4.21.- Hippostasin Serine protease 20 Trypsin-like protease Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2 |
| Gene Name | KLK11 PRSS20 TLSP UNQ649/PRO1279 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MQRLRWLRDWKSSGRGLTAAKEPGARSSPLQAMRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN |
| Enzyme Length | 282 |
| Uniprot Accession Number | Q9UBX7 |
| Absorption | |
| Active Site | ACT_SITE 94; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 142; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 235; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {ECO:0000269|PubMed:10872828, ECO:0000269|PubMed:16467084}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (2); Chain (3); Disulfide bond (6); Domain (1); Glycosylation (4); Natural variant (3); Propeptide (1); Signal peptide (1) |
| Keywords | Alternative splicing;Disulfide bond;Glycoprotein;Golgi apparatus;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus. |
| Modified Residue | |
| Post Translational Modification | PTM: About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen. {ECO:0000269|PubMed:16467084}. |
| Signal Peptide | SIGNAL 1..50; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11550212; 11782391; 12736044; 12845660; 15102682; 15329323; 15893744; 16800740; 18515984; 19184568; 19190824; 19242826; 19383315; 19560453; 20424135; 21520985; 21618246; 22429520; 23602830; 23639975; 23647300; 24169449; 24288670; 25123036; 29095848; 29874189; 29975661; 33015784; 33420975; 34059001; 34067437; 34697154; |
| Motif | |
| Gene Encoded By | |
| Mass | 31,059 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.35;3.4.21.B42; |