| IED ID |
IndEnz0002004188 |
| Enzyme Type ID |
protease004188 |
| Protein Name |
Antitoxin HicB
|
| Gene Name |
hicB ydcQ b1438 JW1433 |
| Organism |
Escherichia coli (strain K12) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Enterobacterales
Enterobacteriaceae
Escherichia
Escherichia coli
Escherichia coli (strain K12)
|
| Enzyme Sequence |
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV |
| Enzyme Length |
138 |
| Uniprot Accession Number |
P67697 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
DNA_BIND 93..112; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00257 |
| EC Number |
|
| Enzyme Function |
FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HicA-mediated cessation of cell growth and inhibition of cell proliferation. {ECO:0000269|PubMed:19060138}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (6); Chain (1); DNA binding (1); Domain (1); Erroneous initiation (1); Helix (5) |
| Keywords |
3D-structure;DNA-binding;Reference proteome;Repressor;Stress response;Toxin-antitoxin system;Transcription;Transcription regulation |
| Interact With |
|
| Induction |
INDUCTION: Induced by amino acid starvation, carbon starvation and when translation is blocked. Induction no longer occurs in the absence of Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the HicB antitoxin. A member of the hicA-hicB operon. {ECO:0000269|PubMed:19060138}. |
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
PTM: May be degraded by Lon protease. {ECO:0000250}. |
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (2) |
| Cross Reference PDB |
6HPB;
6HPC;
|
| Mapped Pubmed ID |
15556475;
24561554;
31495532;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
15,247 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|