| IED ID | IndEnz0002004214 |
| Enzyme Type ID | protease004214 |
| Protein Name |
F-box/WD repeat-containing protein 7 F-box and WD-40 domain-containing protein 7 Protein archipelago |
| Gene Name | ago CG15010 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MERGCPAASSESVTSAGERTQSAVTSSTSTWVKSQASTSRKTEASEESGLGAVDAEVGAGREAFVSMSTLREDVEDVCVSSNSQHGFAVVLDDESSTFEISSSNSLPTSAGAASTVGVVAVDDSSSTDTLNGGHPDLGHPASSEHSRQGFFNEDNEDPPVVCLINDDDDDEEPEPEEDDEEELIEDEDEDAVDIVTGAISCPNTSQLALADGTIMAADGSKIFLETPVVEEAQPHPGQVVTTGSQSELTGKPKRLSDEFLLGEEDQAENLALGRCIKSEPVNPVDDNPSEGDDGATCFSLHDRLMSVRLKQMSLTANTVSNPSPAASANAAAPEEASTSNSSSTSSSALSRADIESMDLIERRDFETEQRLTGGIILRTSSMVSQNKLNLSLIKSMAGGSKAANGSGTANSDDWPSSSNGRTVSSDSKYTYKDLSTTPTSSRKYTNSRLSKSTAKLNLGSSLGASSCSQHRSGSSSTSKSMESSTSCTGAARTDVYTNTNSNDYPSLAPTTSGSSTSGGSCQQDQEENVSASVSYSSVGSQTSQESGCSRTTAINPTAACSTGSACLGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANPTASVRQRRNGSSDVVHLEVVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDFDVEGACVKCS |
| Enzyme Length | 1326 |
| Uniprot Accession Number | Q9VZF4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively (PubMed:11565033, PubMed:15182669). Required for endocycles, but not mitosis in follicle cell epithelium (PubMed:15175253). {ECO:0000250, ECO:0000269|PubMed:11565033, ECO:0000269|PubMed:15175253, ECO:0000269|PubMed:15182669, ECO:0000269|PubMed:24173801}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein modification; protein ubiquitination. |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (5); Domain (1); Modified residue (2); Mutagenesis (2); Region (6); Repeat (7) |
| Keywords | Cell cycle;Nucleus;Phosphoprotein;Reference proteome;Repeat;Ubl conjugation pathway;WD repeat |
| Interact With | Q9W4S7 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | MOD_RES 813; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 825; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11533444; 11565017; 11698190; 11976951; 12097338; 12442174; 12628181; 12737805; 12850443; 14605208; 14616073; 14973280; 15187232; 15454540; 15520277; 15575970; 15710747; 15744048; 15809036; 15834142; 16143599; 16359857; 16421189; 16463014; 16496002; 16603075; 17110495; 17256009; 17311883; 17672901; 17976568; 18084299; 18516287; 18690062; 19026789; 19079254; 19081076; 19084407; 19211674; 19285057; 19346490; 19524517; 19723762; 19733076; 20176921; 20220848; 20400939; 21148181; 21154780; 21364088; 22000799; 22028469; 22037307; 22140513; 22359584; 22629134; 22884096; 23071443; 23105012; 23172856; 23271647; 23459416; 23583758; 24068890; 24086162; 24583474; 24685612; 24778256; 24912190; 25053477; 25294943; 25312911; 25412630; 26092715; 26305360; 26505171; 26760760; 27298020; 28093350; 28619822; 28700947; 29174887; 29309414; 29719260; 30030826; 30031756; 30543770; 30656413; 30685895; 30881374; 31068592; 31131321; 31289041; 31722958; 32297857; 32594913; 32637412; 33382409; 33558234; 33875704; |
| Motif | |
| Gene Encoded By | |
| Mass | 141,361 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |