| IED ID | IndEnz0002004228 |
| Enzyme Type ID | protease004228 |
| Protein Name |
Hemoglobinase EC 3.4.22.34 Antigen Sj32 |
| Gene Name | HAEM |
| Organism | Schistosoma japonicum (Blood fluke) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Trematoda Digenea (flukes) Strigeidida Schistosomatoidea Schistosomatidae (blood flukes) Schistosoma Schistosoma japonicum (Blood fluke) |
| Enzyme Sequence | MFYSIFFIHILRIVLVDCNEYSEENVDDRHKWAVLVAGSNGFENYRHQADVCHAYHVLLSKGVKPEHIITFMYDDIAHNKENPFPGKIFNDYRHKDYYKGVVIDYKGKKVNPKTFLQVLKGDKRAGGKVLKSGKNDDVFIYFTDHGAPGILAFPDDDLHAKPFINTLKYLRQHRRYSKLVIYVEACESGSMFAGLLPTDINIYATTAARPDESSYATFCDDPRISSCLADLYSYDWIVDSEKHQLTQRTLDQQYKEVKFETNLSHVQRYGDKKMGKLYLSEFQGSRKKASTEHDEPPMKPKDSIPSRDIPLHTLHRRIMMANNMNDKTLLMKILGLKLKRRDLIKDTMEVIDQFMFNVKQPNSNATIDETMDCIEVVYKEFQSKCFKIQQAPEITGYLSTLYNYCQKGYSAENINGVIRKVCG |
| Enzyme Length | 423 |
| Uniprot Accession Number | P42665 |
| Absorption | |
| Active Site | ACT_SITE 145; /evidence=ECO:0000255; ACT_SITE 186; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.; EC=3.4.22.34; |
| DNA Binding | |
| EC Number | 3.4.22.34 |
| Enzyme Function | FUNCTION: This protease is used by the parasite for degradation of the host globin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Propeptide (2); Region (1); Signal peptide (1) |
| Keywords | Hydrolase;Protease;Signal;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,938 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.34; |