| IED ID | IndEnz0002004233 |
| Enzyme Type ID | protease004233 |
| Protein Name |
Hatching enzyme HE HEZ EC 3.4.24.12 Envelysin Sea-urchin-hatching proteinase Cleaved into: Hatching enzyme 18 kDa form |
| Gene Name | |
| Organism | Paracentrotus lividus (Common sea urchin) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Echinodermata Eleutherozoa Echinozoa Echinoidea (sea urchins) Euechinoidea Echinacea Camarodonta Echinidea Echinidae Paracentrotus Paracentrotus lividus (Common sea urchin) |
| Enzyme Sequence | MANSGLILLVMFMIHVTTVHNVPLPSTAPSIITQLSDITTSIIEEDAFGLTTPTTGLLTPVSENDSDDDGDDITTIQTTTSSSQTVISGVVVEEGVHESNVEILKAHLEKFGYTPPGSTFGEANLNYTSAILDFQEHGGINQTGILDADTAELLSTPRCGVPDVLPFVTSSITWSRNQPVTYSFGALTSDLNQNDVKDEIRRAFRVWDDVSGLSFREVPDTTSVDIRIKFGSYDHGDGISFDGRGGVLAHAFLPRNGDAHFDDSETWTEGTRSGTNLFQVAAHEFGHSLGLYHSTVRSALMYPYYQGYVPNFRLDNDDIAGIRSLYGSNSGSGTTTTTRRPTTTRATTTRRTTTTRATTTRATTTTTTSPSRPSPPRRACSGSFDAVVRDSSNRIYALTGPYFWQLDQPSPSWGLVSNRFGFGLPQNIDASFQRGVVTYFFSECYYYYQTSTQRNFPRIPVNRKWVGLPCNIDAVYRSSRGPTYFFKDSFVYKFNSNNRLQRRTRISSLFNDVPSALHDGVEAVVRADRNYIHFYRDGRYYRMTDYGRQFVNFPNGLPYSDVIESVIPQCRGRSLSYESEGCSNSSE |
| Enzyme Length | 587 |
| Uniprot Accession Number | P22757 |
| Absorption | |
| Active Site | ACT_SITE 284; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins of the fertilization envelope and dimethylcasein.; EC=3.4.24.12; |
| DNA Binding | |
| EC Number | 3.4.24.12 |
| Enzyme Function | FUNCTION: Allows the sea urchin to digest the protective envelope derived from the egg extracellular matrix; thus allowing the sea urchin to swim freely. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (2); Compositional bias (1); Disulfide bond (1); Glycosylation (4); Metal binding (4); Motif (1); Propeptide (1); Region (1); Repeat (4); Sequence conflict (5); Signal peptide (1); Site (1) |
| Keywords | Autocatalytic cleavage;Calcium;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Repeat;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000305 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 157..164; /note=Cysteine switch; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 65,207 |
| Kinetics | |
| Metal Binding | METAL 159; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 283; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 287; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 293; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |