| IED ID | IndEnz0002004286 |
| Enzyme Type ID | protease004286 |
| Protein Name |
Metacaspase-2 EC 3.4.22.- PfMCA2 |
| Gene Name | MCA2 PF3D7_1438400 |
| Organism | Plasmodium falciparum (isolate 3D7) |
| Taxonomic Lineage | cellular organisms Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida (haemosporidians) Plasmodiidae Plasmodium Plasmodium (Laverania) Plasmodium falciparum Plasmodium falciparum (isolate 3D7) |
| Enzyme Sequence | MNSMNTYSPLYSSYENINIYKKNRKFEEDNYETSTANISCDSKGRILVKESENDRNESIQKKQMLSSMDNRKTNKSEKHNISSYYKMRKKASNHLKDKEKLNNNIIYAKNPHANRYDKYYSLNMNIMNNMNNMNNMNNVNNMNNVNNMNNVNNMNNMNNVNNMNNMNNVNNMNNVKSMYNNNNNSNVYYRISRQNINGKERLLNRYNIMRPQRSADMLIRNYLYNDLPYEINQQNLNKNINDNNAGSFDNLNKTVFENYNKNILDEYNRNIMQYYNSNLKNYRNSSFDNIYTRYNNNNNNNNVYSNNNVYSNNNIYNNNNNNDNINNSFQFSKQEGLMKIYSNNNRNMNDYVVKTSNITRAADNTCAQEQINIPTYNKTVLLKSSPNTENTFNKTLSNILKEQPKRSSMFSFNSSDFFKDFGKLRKNFVGKKKNKINKDIVINGNIFNNKIIDNNTSNAKSEGNSTLHKIYNFIFPSSVKKLQKKKQKLQVIEDKEKNSNRAVVMPLKNKIIYINDANITNDKFKHSFENYNYHQTNIPFVSVTNYMNKDSTKNVRSFSSFDVKERISPRVIRNGNINNNKNNNINNNNNNINNNNNNINNNNNNINNNNNINNNNNINNNNNINNNNNINNNNINNINNINNDFVNDSNINKTVNIHNNNNNLNNYSNTMKSVAKNTQKLSAQKNSLVNDKHHTYHEKLITNIYQFTGGQSQKSCNIKNQNVKEEKINNTQISYINNTAYNDYTNLPNVETYVLSEKSNNLENKEDNNINEKFKNDNNVDKKNNDENNIIKHNVNQNNNEVIVMNNQTEEQINDNKFIKPLNNITGIDPKKKNIYNTVMHINDKMDLNKHDYNYNYNNIIPHNYINSSDKMTNNSLHINKKADDIFQNMISNNDTNVPCVYVNKYINNIFQNNNPSNVTNYINTINMNKAPITIDENSNKLDNNINYENVTKNMIYNNYTNNNVLYITKEKSDNKLNNSTNHLNDLKNNYYVINPSLLYIHNNNNNIEWNKQYTNNFSKPNFLDKFFYEKKVESIQPHHLNQYYYNNQNVKYNPSHINILENKYVNQFTNQNENSLYNFTTHHNNIKNNNIDNILLLDKAIRNQSIYYNNNKGDDETKSAEHTTNPSINLLKNNYEDKNKSNYVHSIVSITDKDNSIYAKNKYAEVVTKNNEKREDAIHKKDEQYIFNNNDNNNDNIHNNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIDVSSRENFFQHDIQNTNQINNKTILDITQNEKPNATNEKCLDINNKEKKKKKIKSVHYDMDEILSLKCKVYDELDTCLKCINNLTKNKKLYEQLKKYKHKLDKDTKTKKLYDECTSEKTGSYYTMKDSYISSLLCNEYKLNHILNKSNNKVSDDKHILSYNHHHNKNNNINDINNIKHISKFVNKDNEKTLNNINILNHNNKDPNSGVFLPSDNTESVIYNMNRNRKLCDNNFNVSKHVLYKDSKGTDSTRTNFYDDYSMSYVKSNVDNVEKKEKIKNNINISDKYFLSETDSPYIGKKKALMITLNYNGLLEGCVNDTVDMCDHLMQRFGFNDFILLNDCNLCYRNFVTQKANKKNILSNLHNFIVNSNNGDILFFYFCGYSIKLIDSKFTENYNFALLPQDHSKNNYIYSNEIFNIIKKLQGGKQLCIIFDTTYTSYFVPVPTSITYNKNMNTTEIYKYNNFSSNQKYLKSLKTFGKIRDRNVDSIFVENIKKPLLYEIYKKENDTNTNDKIILVPSIFFFSPDCNDRNDFEFSIKNKVRGLLTYCLGKAIELLKNDFSYHDLFVAASQILIDIKKEYNLKYVKFKLSFLNEYSPDDIKFLSHESLFLKKKLQLDEPLWKPSLKLNNLNQYIQDICNMDERKMLKSSKKKCLLIFIKDIKFYTYKNIDTKNEYFVSCFIKNKNVNILCVRRNNTKEQRIVQDKIFFLEYITLNVTHMENANIYVELFKKKKKNYFVARSIFNIRNVNGKFSLSDEKKNIIGIIDLNIKCVS |
| Enzyme Length | 2020 |
| Uniprot Accession Number | Q8IL84 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Ca(2+) does not appear to affect catalytic activity. {ECO:0000269|PubMed:29317266}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Protease that cleaves specifically after arginine or lysine residues (PubMed:29317266, PubMed:32202613). May play a role in parasite growth and/or development (PubMed:29317266, PubMed:32202613). {ECO:0000269|PubMed:29317266, ECO:0000269|PubMed:32202613}. |
| Temperature Dependency | |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:29317266}; |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Region (2) |
| Keywords | Cytoplasm;Hydrolase;Protease;Reference proteome |
| Interact With | |
| Induction | INDUCTION: Up-regulated by oxidative stress. {ECO:0000269|PubMed:29317266}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29317266}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16267556; |
| Motif | |
| Gene Encoded By | |
| Mass | 237,831 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |