| IED ID | IndEnz0002004312 |
| Enzyme Type ID | protease004312 |
| Protein Name |
Eukaryotic translation initiation factor 3 subunit E AtEIF3E-1 eIF3e p48 Eukaryotic translation initiation factor 3 subunit 6 AtINT6 INT-6 |
| Gene Name | TIF3E1 INT6 At3g57290 F28O9.140 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MEESKQNYDLTPLIAPNLDRHLVFPIFEFLQERQLYPDEQILKSKIQLLNQTNMVDYAMDIHKSLYHTEDAPQEMVERRTEVVARLKSLEEAAAPLVSFLLNPNAVQELRADKQYNLQMLKERYQIGPDQIEALYQYAKFQFECGNYSGAADYLYQYRTLCSNLERSLSALWGKLASEILMQNWDIALEELNRLKEIIDSKSFSSPLNQVQNRIWLMHWGLYIFFNHDNGRTQIIDLFNQDKYLNAIQTSAPHLLRYLATAFIVNKRRRPQLKEFIKVIQQEHYSYKDPIIEFLACVFVNYDFDGAQKKMKECEEVIVNDPFLGKRVEDGNFSTVPLRDEFLENARLFVFETYCKIHQRIDMGVLAEKLNLNYEEAERWIVNLIRTSKLDAKIDSESGTVIMEPTQPNVHEQLINHTKGLSGRTYKLVNQLLEHTQAQATR |
| Enzyme Length | 441 |
| Uniprot Accession Number | Q9C5Z3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Regulates negatively translation during flower development (PubMed:18067529, PubMed:20444226). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:18067529, ECO:0000269|PubMed:20444226}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Erroneous gene model prediction (1); Sequence conflict (5) |
| Keywords | Cytoplasm;Developmental protein;Initiation factor;Nucleus;Protein biosynthesis;Reference proteome;Repressor;Translation regulation |
| Interact With | Q9LEZ3; Q94JU3; O49160; Q84MB2 |
| Induction | INDUCTION: Targeted by the COP9 signalosome to proteasome-dependent degradation. {ECO:0000269|PubMed:18067529}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:11029466}. Nucleus {ECO:0000269|PubMed:11029466}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17317660; 17916636; 18775970; 18854373; |
| Motif | |
| Gene Encoded By | |
| Mass | 51,750 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |