| IED ID | IndEnz0002004314 |
| Enzyme Type ID | protease004314 |
| Protein Name |
Putative endoplasmic reticulum metallopeptidase 1-B EC 3.4.-.- FXNA-like protease |
| Gene Name | C44B7.11 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MSTGIRRRHADEKKNILEKESLQNDETQREMEKDISLLRPAHWNFIGLFFLVLIIGTTFLHKCLPEPKDPNQEETQFSEKRAVKVLQELSDYGWKPAGSYNCEELTRNRILKELNDIRSQNQNVENLRFDIDTQYVSGCFDIPAHDTEGMNICYRNVSNVMARLGKGEKKDKISVLLNCHYDSWPTSNAGSDDLSSCALMLELIRLYSKNPHLLNHDVIFLFNGAEESSLLAAHGFITQHSWRHEIRAFINLEASGSGGRELLFQAGPANQWLLNSYLEAAIHPHCSVIGQEVFQSGVYPGDTDFRIFRDHGRVPGLDLAFVQNGYWWHTEFDTAERITKGSLQRAGENVYSTLNHLLKSPYLEKPAEYADRKTVFFDFLGLFVIIYPLSIAHLVNMLTICTVIALMSHRFYSKTFITFLALRDYVLTILTIALVLKAMTFMSLFTYGALRWYTRHWLALVAYGLPSVWAGISVQGLLTARLAPKAREEYGSTLELIHLTLISGILLAFTYYDIASGFLFALLLVPAIKSIITYFGAWPTCPTFNTILTLILSFPGCAMAIYTTEMLLSIFIPIMGRSSYNPEPAVSFFVAFSAGCIVLSLGGLVAKSRNSRSSNEAGLLELIYNILGVLLVTLTILYVFSSFWPSPYRFDNVYPTAKRTQFFHVNQMLYDRNGQISVNDTRFYAISHDYRGAEDIPFVKKDPEYTGLQCHYENNPWCETPFLFPTKGRLNERNIRVRSVDERLKFKHPVKILGISKRHGVDSKDGKGNIEYSFSVIGTGQISVYIIPDTTWLITNTSVTQPKTPQENMFLYYTCSTPNNICEWMFKVTIKKTTQTPSDDKPLLIGISSHYLHGPEMQSESIKNMIAKIQENRVNSPEWTVTASAWNVDQVYKYF |
| Enzyme Length | 895 |
| Uniprot Accession Number | Q18600 |
| Absorption | |
| Active Site | ACT_SITE 226; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (3); Metal binding (6); Region (1); Topological domain (10); Transmembrane (9) |
| Keywords | Coiled coil;Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6UPR8}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 17164286; 19343510; 20610404; 21085631; 21177967; 21367940; 22267497; 22286215; 22347378; 22560298; 23800452; 24884423; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 101,896 |
| Kinetics | |
| Metal Binding | METAL 180; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 192; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 192; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 227; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 253; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 329; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |