| IED ID | IndEnz0002004326 |
| Enzyme Type ID | protease004326 |
| Protein Name |
Gag polyprotein Pr53Gag Cleaved into: Matrix protein p19 MA ; Capsid protein p24 CA ; Nucleocapsid protein p15-gag NC-gag |
| Gene Name | gag |
| Organism | Human T-cell leukemia virus 3 (strain Pyl43) (HTLV-3) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Deltaretrovirus Primate T-lymphotropic virus 3 Human T-cell leukemia virus 3 (strain Pyl43) (HTLV-3) |
| Enzyme Sequence | MGKTYSSPVNPIPKAPKGLAIHHWLNFLQAAYRLQPGPSEFDFHQLRKFLKLAIKTPVWLNPINYSVLARLIPKNYPGRVHEIVAILIQETPAREAPPSAPPADDPQKPPPYPEHAQVEPQCLPVLHPHGAPATHRPWQMKDLQAIKQEVSSSAPGSPQFMQTVRLAVQQFDPTAKDLHDLLQYLCSSLVASLHHQQLETLIAQAETQGITGYNPLAGPLRVQANNPNQQGLRREYQNLWLSAFSALPGNTKDPTWAAILQGPEEPFCSFVERLNVALDNGLPEGTPKDPILRSLAYSNANKECQKLLQARGQTNSPLGEMLRACQTWTPRDKNKILMIQPKKTPPPNQPCFRCGQAGHWSRDCKQPRPPPGPCPLCQDPAHWKQDCPQLKADTKGSEDLLLDLPCEASHVRERKNSSGGED |
| Enzyme Length | 422 |
| Uniprot Accession Number | Q09T00 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). {ECO:0000250}.; FUNCTION: Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. {ECO:0000250}.; FUNCTION: Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (3); Compositional bias (1); Initiator methionine (1); Lipidation (1); Motif (2); Region (1); Site (2); Zinc finger (2) |
| Keywords | Capsid protein;Host-virus interaction;Lipoprotein;Metal-binding;Myristate;Phosphoprotein;Repeat;Ribosomal frameshifting;Viral nucleoprotein;Virion;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Matrix protein p19]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p15-gag]: Virion {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: Specific enzymatic cleavages by the viral protease yield mature proteins. The polyprotein is cleaved during and after budding, this process is termed maturation (By similarity). {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 98..101; /note=PTAP/PSAP motif; MOTIF 109..112; /note=PPXY motif |
| Gene Encoded By | |
| Mass | 46,938 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |