| IED ID | IndEnz0002004359 |
| Enzyme Type ID | protease004359 |
| Protein Name |
ATP-dependent zinc metalloprotease FTSH 3, mitochondrial AtFTSH3 EC 3.4.24.- |
| Gene Name | FTSH3 At2g29080 T9I4.16 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MTMIFFSKLNRSISRSKGFLYGGGVRSAARLLTSPGLEAASVNEVEGGLGFIRRHFASLASRKGLVNNDLIGVFANPRLRRFFSDEAPKKKNYENYFPKDKQEPKSDQKSEHKEGSEKNENENVGDMFMNRFQNLLIPLLALAVFFSTFSFGSGEQQQISFQEFKNKLLEPGLVDHIDVSNKSVAKVYVRSTPKDQQTTDVVHGNGNGIPAKRTGGQYKYYFNIGSVDSFEEKLEEAQEALGVDRHEYVPVTYVSEMVWYQEFMRFAPTLLLLGTLIYGARRMQGGLGVGGTGGKNGRGIFNIGKATITRADKHSKNKIYFKDVAGCDEAKQEIMEFVHFLKNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPSRVRHLFQEARQAAPSIIFIDEIDAIGRARGRGGLGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFKIYLKKIKLDHEPSYYSQRLAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFESAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVVGWFLEHAEPLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVLIGKISTGAQNDLEKVTKMTYAQVAVYGFSDKVGLLSFPPRDDGYDFSKPYSNKTGAIIDEEVRDWVAKAYERTVELVEEHKVKVAEIAELLLEKEVLHQDDLLKILGERPFKSAEVTNYDRFKSGFEETEKDSAATPTVEPVVDDGAPPPFEPQVVPT |
| Enzyme Length | 809 |
| Uniprot Accession Number | Q84WU8 |
| Absorption | |
| Active Site | ACT_SITE 587; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system. {ECO:0000269|Ref.10}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 362..369; /note=ATP; /evidence=ECO:0000255 |
| Features | Active site (1); Chain (1); Compositional bias (2); Erroneous initiation (1); Metal binding (3); Nucleotide binding (1); Region (2); Sequence conflict (3); Transit peptide (1); Transmembrane (1) |
| Keywords | ATP-binding;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Nucleotide-binding;Protease;Reference proteome;Transit peptide;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | INDUCTION: By heat and high light. {ECO:0000269|PubMed:15266057}. |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:14671022, ECO:0000269|Ref.10}; Single-pass membrane protein {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:14671022, ECO:0000269|Ref.10}; Matrix side {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:14671022, ECO:0000269|Ref.10}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12185496; 15322131; 17181860; 20172857; 21438879; 22121866; 24064926; 29462458; |
| Motif | |
| Gene Encoded By | |
| Mass | 89,353 |
| Kinetics | |
| Metal Binding | METAL 586; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 590; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 662; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.B20; |