| IED ID | IndEnz0002004415 |
| Enzyme Type ID | protease004415 |
| Protein Name |
Plasminogen activator inhibitor 2 PAI-2 Monocyte Arg-serpin Placental plasminogen activator inhibitor Serpin B2 Urokinase inhibitor |
| Gene Name | SERPINB2 PAI2 PLANH2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP |
| Enzyme Length | 415 |
| Uniprot Accession Number | P05120 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (18); Chain (1); Disulfide bond (1); Glycosylation (3); Helix (12); Natural variant (5); Sequence conflict (1); Signal peptide (1); Site (1); Turn (6) |
| Keywords | 3D-structure;Cytoplasm;Direct protein sequencing;Disulfide bond;Glycoprotein;Plasminogen activation;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | PTM: The signal sequence is not cleaved. |
| Signal Peptide | SIGNAL 1..?; /note=Not cleaved |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 1BY7; 1JRR; 2ARQ; 2ARR; |
| Mapped Pubmed ID | 11546761; 11929770; 11949838; 12105855; 12578825; 12682008; 12944478; 14653443; 15500643; 15767426; 15887231; 16038020; 16113755; 16214170; 16459332; 16923810; 17141398; 17267840; 17657675; 17696882; 18472001; 18632617; 18690354; 18977990; 19074642; 19117638; 19238444; 19423540; 19650060; 19690890; 19913121; 19926580; 20406964; 20438785; 20494554; 20562859; 20628086; 20628624; 20800603; 20838737; 20845058; 20974129; 21314733; 21316840; 21477997; 21606492; 2166055; 21744990; 21976669; 22334683; 23188538; 23460840; 23474086; 23527801; 23544109; 23661500; 23874812; 23897640; 24265642; 25046655; 25444509; 25775950; 26083412; 26573152; 27174532; 27558531; 27598010; 28346421; 28427146; 28578223; 28794016; 28817461; 28883483; 29120588; 29347950; 29925837; 30600477; 30864656; 3090045; 31080015; 31176714; 31801690; 32404981; 32780555; 33227315; 33387293; 34095322; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,596 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |