| IED ID | IndEnz0002004429 |
| Enzyme Type ID | protease004429 |
| Protein Name |
Mitochondrial metalloendopeptidase OMA1 EC 3.4.24.- |
| Gene Name | OMA1 CAALFM_C404550CA orf19.3827 |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Candida/Lodderomyces clade Candida Candida albicans (Yeast) Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Enzyme Sequence | MFGSKIFSRLFFKRTYATYKRFDNTTSSSSFTTSYAHLLTNRKTLYIGGGLLGFYVYNLHDAPYTHRSRFIWVPYWLETKIGDYSYRQIYQQFQSQILPHSNPLYNRVSTIMNKLLDVALNDNINDDLNARFLNHLKSLKWEINIIQNDSLPPNAFILPNGKIFIFSSIMPICKNEDGLATVLSHELSHQLAQHSSEQLSKQPIYMVLSTILYTITGVSWFNDLLINGVLTMSASREMESEADHIGCELLARACFNPQESINFWHRMSQAEKKAAGIVSQEGGYLNTWEFFSTHPATSRRIADIQKWMPQLLQIRESSGCYEYGRFYNFNKSYFSH |
| Enzyme Length | 336 |
| Uniprot Accession Number | Q5A663 |
| Absorption | |
| Active Site | ACT_SITE 186; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | ACTIVITY REGULATION: Protease activity is induced in response to various mitochondrial stress. {ECO:0000250|UniProtKB:P36163}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Protease that is part of the quality control system in the inner membrane of mitochondria (By similarity). Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane protein (By similarity). Required for TOR signaling (PubMed:27325672). {ECO:0000250|UniProtKB:P36163, ECO:0000269|PubMed:27325672}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (1); Metal binding (3); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P36163}; Single-pass membrane protein {ECO:0000250|UniProtKB:P36163}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 38,971 |
| Kinetics | |
| Metal Binding | METAL 185; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 189; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 239; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |