| IED ID |
IndEnz0002004434 |
| Enzyme Type ID |
protease004434 |
| Protein Name |
Counting factor associated protein D
|
| Gene Name |
cfaD DDB_G0281605 |
| Organism |
Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Amoebozoa
Evosea
Eumycetozoa
Dictyostelia (dictyostelid cellular slime molds)
Dictyosteliales
Dictyosteliaceae
Dictyostelium
Dictyostelium discoideum (Slime mold)
|
| Enzyme Sequence |
MNKFILLLSLVTLSCVLAVPQLPAAQQYYMKGSFNIPYFNIVEPIELIYDSVNNRQYISVYNGMDITINFYNQDNTYNVGPVKYDMVCTTTPGNGSLVNVLPTEPSSWVYNGTSTVNGVQVFGYSQKITQYGRTGFYNFYVDANGVPVQFYMDGVDYVFGSHPDVYVLNFDIYTTDISSYESYFDIPVLCNNAKEAPAKENQFDGLFSSIGDNLLAKEEQASNLFKEYKAQYNKEYSSQDEHDERFINFKAARKIIATHNAKESSYKLGMNHYADLSNKEFNTLVKPKVARPSVTGADSVHDDESLRSIPSTVDWRNQNCVTPVKDQGICGSCWTFGSTGSLEGTNCVTNGELVSLSEQQLVDCAILTGSQGCGGGFASSAFQYVMEIGSLATESNYPYLMQNGLCRDRTVTPSGVSITGYVNVTSGSESALQNAIATTGPVAIAIDASVDDFRYYMSGVYNNPACKNGLDDLDHEVLAIGYGTYQGQDYFLVKNSWSTNWGMDGYVYMARNDNNLCGVSSQATYPIPTKN |
| Enzyme Length |
531 |
| Uniprot Accession Number |
Q54TR1 |
| Absorption |
|
| Active Site |
ACT_SITE 333; /evidence=ECO:0000250; ACT_SITE 475; /evidence=ECO:0000250; ACT_SITE 495; /evidence=ECO:0000250 |
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity. {ECO:0000269|PubMed:18611962, ECO:0000269|PubMed:19187549}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Active site (3); Chain (1); Disulfide bond (3); Glycosylation (3); Signal peptide (1) |
| Keywords |
Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18611962, ECO:0000269|PubMed:19187549}. Note=Concentrated in subcellular structures, possibly vesicles. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
16234315;
19635129;
20422638;
21521184;
21760904;
22120990;
22711818;
23555023;
24390142;
24726820;
24797076;
25330233;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
58,638 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|