| IED ID | IndEnz0002004448 |
| Enzyme Type ID | protease004448 |
| Protein Name |
Putative annexin A2-like protein Annexin A2 pseudogene 2 Lipocortin II pseudogene |
| Gene Name | ANXA2P2 ANX2L2 ANX2P2 LPC2B |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNIVTNRDNAQRQDIVFSYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDAQDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQRIQNKPLYFADQLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD |
| Enzyme Length | 339 |
| Uniprot Accession Number | A6NMY6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Initiator methionine (1); Modified residue (6); Region (1); Repeat (4); Sequence conflict (2) |
| Keywords | Acetylation;Annexin;Basement membrane;Calcium;Calcium/phospholipid-binding;Extracellular matrix;Phosphoprotein;Reference proteome;Repeat;Secreted |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane. In melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. {ECO:0000250}. |
| Modified Residue | MOD_RES 2; /note=N-acetylserine; /evidence=ECO:0000250|UniProtKB:P19620; MOD_RES 24; /note=Phosphotyrosine; by SRC; /evidence=ECO:0000250; MOD_RES 49; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:P07356; MOD_RES 152; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:P07356; MOD_RES 199; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P07356; MOD_RES 227; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:P07356 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 19615732; 20000738; 20562859; 21182205; 21555518; 23386615; 30881525; 32707073; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,659 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |