| IED ID |
IndEnz0002004449 |
| Enzyme Type ID |
protease004449 |
| Protein Name |
Boophilin-H2
|
| Gene Name |
H2 |
| Organism |
Rhipicephalus microplus (Cattle tick) (Boophilus microplus) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Chelicerata
Arachnida
Acari
Parasitiformes
Ixodida (ticks)
Ixodoidea
Ixodidae (hardbacked ticks)
Rhipicephalinae
Rhipicephalus
Boophilus
Rhipicephalus microplus (Cattle tick) (Boophilus microplus)
|
| Enzyme Sequence |
MKCIILLAVLGTAFAQRNGFCRLPADEGICKALIPRFYFNTETGKCTMFSYGGCGGNENNFETIEECQKACGAPERVNDFESADFKTGCEPAADSGSCAGQLERWFYNVQSGECETFVYGGCGGNDNNYESEEECELVCKNM |
| Enzyme Length |
142 |
| Uniprot Accession Number |
Q8WPI2 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Prevents blood clot formation to allow successful feeding and digestion through its inhibition activity of thrombin and other host anticoagulating factors like kallikrein, coagulation factor VII, or plasmin. {ECO:0000269|PubMed:18286181}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (6); Chain (1); Disulfide bond (6); Domain (2); Helix (4); Signal peptide (1); Turn (2) |
| Keywords |
3D-structure;Direct protein sequencing;Disulfide bond;Protease inhibitor;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
2ODY;
|
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
15,538 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|