| IED ID | IndEnz0002004460 |
| Enzyme Type ID | protease004460 |
| Protein Name |
COP9 signalosome complex subunit 5 EC 3.4.-.- |
| Gene Name | RRI1 CSN5 FGRRES_02584 FGSG_02584 |
| Organism | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Nectriaceae Fusarium Fusarium sambucinum species complex Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum) Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) |
| Enzyme Sequence | MEASALKAWELDNNVQLVDPKRDALYNFDADAQKAINKEQPWKQDPSHFKHVRISATALIKMTMHARSGGNLEVMGLMQGYTQGDTFIVTDAFRLPVEGTETRVNAQDEANEYIVEYLDLCRAQGRQENVVGWYHSHPGYGCWLSGIDVDTEAMQQQFQDPFLAVVIDPDRTINSGKVDIGAFRTYPADYKPSGGVTSDGFQAVPLAKAAEFGAHASRYYSLEVSHFKSSLDSHLLELLWHKYWVQTLSQNPLITNRDYGNKQLLDLSSKIKEATTGITRNRAGQGMMMGMSTKSSDKAVDKLAKEANLIASKERSGLIANQVKASLFNDLGSKANPTSE |
| Enzyme Length | 340 |
| Uniprot Accession Number | Q4IJM4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (3); Motif (1) |
| Keywords | Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Nucleus;Protease;Reference proteome;Signalosome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 135..148; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 37,744 |
| Kinetics | |
| Metal Binding | METAL 135; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 137; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 148; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda |