| IED ID | IndEnz0002004462 |
| Enzyme Type ID | protease004462 |
| Protein Name |
Caspase-1 EC 3.4.22.- Cleaved into: Caspase-1 subunit p22; Caspase-1 subunit p13 |
| Gene Name | Dcp-1 CG5370 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFGDKPNGNKAG |
| Enzyme Length | 323 |
| Uniprot Accession Number | O02002 |
| Absorption | |
| Active Site | ACT_SITE 154; /evidence=ECO:0000250; ACT_SITE 196; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (2); Propeptide (2) |
| Keywords | Apoptosis;Direct protein sequencing;Hydrolase;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10037791; 10074440; 10077606; 10407412; 10471706; 10481910; 10511707; 10521468; 10559952; 10591654; 10619022; 10733594; 10764741; 10825159; 10908589; 11042680; 11048731; 11139272; 11139274; 11139276; 11139278; 11139280; 11178240; 11237461; 11337486; 11805061; 12006672; 12011068; 12070100; 12072176; 12473344; 12478468; 12563030; 12593804; 12692559; 12695332; 12885559; 12917412; 12938178; 14644196; 14657035; 14704173; 14744432; 14976192; 15355784; 15547953; 15580265; 15601858; 15657059; 15704171; 15860727; 16099837; 16198289; 16222340; 16369566; 16485033; 16632473; 16645642; 16763555; 16816412; 16887831; 16906130; 16980627; 17027478; 17178403; 17194782; 17275304; 17341581; 17347664; 17435251; 17464325; 17612403; 17634097; 17708965; 18259196; 18331718; 18794330; 18797514; 19182545; 19196346; 19224859; 19232093; 19330035; 19339992; 19651888; 19737742; 19818615; 19960024; 20100334; 20220848; 20371351; 20445064; 21074052; 21104369; 21113144; 21120926; 21177345; 21267420; 21775776; 22153373; 22240900; 22351928; 22539005; 22817988; 22981648; 22992958; 23028118; 23071443; 23087837; 23519152; 23523076; 23532117; 23784845; 23846225; 23943356; 23944235; 24098761; 24239163; 24819984; 24862573; 24891502; 24907259; 24949430; 24967585; 25255315; 25312911; 25332163; 25668151; 25855961; 25882045; 25941003; 25970035; 26010168; 26022392; 26069889; 26092528; 26173873; 26362609; 26374522; 26413413; 26551273; 26655374; 26840050; 26870755; 26900934; 27095493; 27172210; 27177021; 27256879; 27317808; 27527793; 27558818; 27923046; 27999411; 28085885; 28455414; 28524858; 28688927; 28751499; 28806103; 28808034; 28870988; 28893998; 28945745; 29050293; 29084807; 29231806; 29385168; 29403026; 29447906; 29750169; 29752350; 29787709; 29870691; 30022065; 30095068; 30159848; 30379844; 30563404; 30735120; 30837828; 30901309; 31063760; 31255773; 31283922; 31287057; 31390535; 31391501; 31409797; 31438818; 31492772; 31548372; 31641960; 31745213; 31772150; 31822470; 32097403; 32380032; 32550498; 32573699; 32658991; 32737445; 32760283; 32894223; 32946789; 33135280; 33184261; 33300258; 33377870; 33495632; 33556132; 33683366; 33770070; 33863891; 33983927; 34146466; 34200604; 34349099; 34463269; 34599173; 9196327; 9321398; 9342343; 9422696; 9606979; 9714597; 9786886; 9814699; 9916984; 9988219; |
| Motif | |
| Gene Encoded By | |
| Mass | 35,927 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.36; |