| IED ID | IndEnz0002004478 |
| Enzyme Type ID | protease004478 |
| Protein Name |
Putative zinc carboxypeptidase EC 3.4.17.- |
| Gene Name | PF3D7_0103400 PFA0170c |
| Organism | Plasmodium falciparum (isolate 3D7) |
| Taxonomic Lineage | cellular organisms Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida (haemosporidians) Plasmodiidae Plasmodium Plasmodium (Laverania) Plasmodium falciparum Plasmodium falciparum (isolate 3D7) |
| Enzyme Sequence | MLFKNEDSGNGVYCFTYNNFSDVTISDILNIRNDNKNNDNEDNKQDDEEKNDEDDNKSNLLLEENEENKRQGDKPFEDLSLFSFKNNEQCYDNIKMQQAILNSSYEKNVKNIVKIVYHEDCKLLYENTDIHVELPSIVYGRNRNKNNDVVNKCNQYNDDDYTNKCNQYNDDDYTNKCNQYNDDDYTNKCNQYNDNDYTNKCNQYNDNDYTNKCNQYNDVRKITNLKYFINHNWKNINLINEKLFLKNLKELEEILNYNFLHICKNKCKQYNKKRKNERHFSYHDNFLSHYIIYKKNKFIKHNKNEHINGNHYDAHESTNTYDEEKTREKHNNKNNNMKYCLNKYPYDNVNAPLNLSCPWYEKKIENIYCLNIPGYKYKYKYICPSMSKMNDEKIKELYIPKGHILFNSKFESGNLKYVIKEENDKEVYSLFLNPDIRMNEKKNQWFYFSASYVPNEYYTNELYKMKMCNKDINHIGDNMNVVYNYMNGTGNNINNIVNNLDSTVNYMNSTGNNINNIVNNLDSTVNYMNSTGNNINNIVNNLDSTVNYMNSTGNNINNIVNNLDSTVNYMNSTGNYLNRKNNNHLSYTNWSGQRCMNQYLNDINNDEIDTNLDGNRKYSLDACDKFTVRNVRKLEKPFTVRFKIENMAKPFFLYKYGHSPLSFSECKYKIENIQWERNSYDIKYIKNSSCKHYNIKKNSMEYYNYNTYTLEFSYDFTYAYDTVYFASSYPYTYSYLSEYLCLIRNLLKDHPTINYIEERLCKTSCGFDCPVLCITNYDRMEEYNKEELKESVEKKQNIVEANNTCDEKLVDGMDISSNAIRKEIKKKGYILTSKKLDKNRVVNNLFVDMKNGCTRGCASGCTNGCANGYTNGYTNRYTKGCTKGCTNEYSNDNMCKECLDIKNICYQEEKEKCDIIKYNDDKDYSHNCCYEECYNMKREKKKFVCCLSDKCNSFLNEQIKRRRSIMGWNILRNRIKCCKNKMYTSNDFMKTFDSLLKKVYVCKGENKKNNGTKIIKRFEEKYDNNLLFKRKDEKRSLSASPKKKKKKKKKIIVLTARVHPGETNSSYAIHGFIAFIISNNIYAHILREKFIFIIIPMLNIDGVILGNNRYCYNGFDLNRQWSNPIGYIHPTIYSAKLLMKNISENNKIIFFCDFHSHSRKYNCFIFGNEGSYNYVKNKKMCEVFPEIYSHTLPWFALVDTVYKADNENKGSARLISGKEFSLDCSYTFEISLFGIQIRKDFNIMYDEKKDIFYVQNYFEGYQNGDDNIKGGDNIKGGDNIKGDDNINGDDNIKGGDNIKGDDNIKRDDNFQRDDNFQRDDNFQRGDNFHRGDNFHRDDIYDKMNKHYINNNYYYDKNSYDFLYFDENLLFMTGVSFGICLFKFINFLSYHKSSICRRTCEEKEKEHISTETCGILCAKNNKDDEEKCNESKKQNHDAFKTGNSLEFDKGEEHLLSDTHRMVNTFLCNSMNKSKNKNKNKKGYNYILNKYGFIKLKSSKKHIEEVKRIRKLKKKKYMVKEVYELGRKIKQNKYYHNYPFGLYKVNINDVIRILNKINMDDPNGKYKGPGFNNSVDMKKKIKNKNESKTEKKSKTENKSKSKSKNKSKSKNKSKRKKVIVIL |
| Enzyme Length | 1620 |
| Uniprot Accession Number | Q8I2A6 |
| Absorption | |
| Active Site | ACT_SITE 1109; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:P00730 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (3); Glycosylation (15); Metal binding (3); Region (5); Topological domain (2); Transmembrane (1) |
| Keywords | Carboxypeptidase;Glycoprotein;Hydrolase;Membrane;Merozoite;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 191,963 |
| Kinetics | |
| Metal Binding | METAL 1059; /note=Zinc; /evidence=ECO:0000250|UniProtKB:P00730; METAL 1062; /note=Zinc; /evidence=ECO:0000250|UniProtKB:P00730; METAL 1155; /note=Zinc; /evidence=ECO:0000250|UniProtKB:P00730 |
| Rhea ID | |
| Cross Reference Brenda |