| IED ID | IndEnz0002004481 |
| Enzyme Type ID | protease004481 |
| Protein Name |
Cathepsin O EC 3.4.22.42 |
| Gene Name | CTSO CTSO1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV |
| Enzyme Length | 321 |
| Uniprot Accession Number | P43234 |
| Absorption | |
| Active Site | ACT_SITE 132; /evidence=ECO:0000250; ACT_SITE 269; /evidence=ECO:0000250; ACT_SITE 289; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.; EC=3.4.22.42; |
| DNA Binding | |
| EC Number | 3.4.22.42 |
| Enzyme Function | FUNCTION: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (2); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | Q92993; Q8TAP4-4; P17252; Q15047-2; P61981 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10072072; 10631941; 10748235; 10809954; 11684289; 11813165; 11853874; 12078484; 12742663; 12748383; 16181339; 19786962; 20711500; 23009386; 26482374; 28968398; 8687433; 9539769; 9545226; |
| Motif | |
| Gene Encoded By | |
| Mass | 35,958 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |