| IED ID | IndEnz0002004482 |
| Enzyme Type ID | protease004482 |
| Protein Name |
Viral cathepsin V-cath EC 3.4.22.50 Cysteine proteinase CP |
| Gene Name | VCATH |
| Organism | Bombyx mori nuclear polyhedrosis virus (BmNPV) |
| Taxonomic Lineage | Viruses Naldaviricetes Lefavirales Baculoviridae Alphabaculovirus Bombyx mori nuclear polyhedrosis virus (BmNPV) |
| Enzyme Sequence | MNKILFYLFVYAVVKSAAYDPLKAPNYFEEFVHRFNKNYSSEVEKLRRFKIFQHNLNEIINKNQNDSAKYEINKFSDLSKDETIAKYTGLSLPTQTQNFCKVILLDQPPGKGPLEFDWRRLNKVTSVKNQGMCGACWAFATLGSLESQFAIKHNELINLSEQQMIDCDFVDAGCNGGLLHTAFEAIIKMGGVQLESDYPYEADNNNCRMNSNKFLVQVKDCYRYIIVYEEKLKDLLPLVGPIPMAIDAADIVNYKQGIIKYCFDSGLNHAVLLVGYGVENNIPYWTFKNTWGTDWGEDGFFRVQQNINACGMRNELASTAVIY |
| Enzyme Length | 323 |
| Uniprot Accession Number | P41721 |
| Absorption | |
| Active Site | ACT_SITE 136; /evidence=ECO:0000250; ACT_SITE 269; /evidence=ECO:0000250; ACT_SITE 289; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.; EC=3.4.22.50; |
| DNA Binding | |
| EC Number | 3.4.22.50 |
| Enzyme Function | FUNCTION: Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (1); Propeptide (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 36,922 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.50; |