| IED ID | IndEnz0002004489 |
| Enzyme Type ID | protease004489 |
| Protein Name |
Rhizopuspepsin EC 3.4.23.21 Fragment |
| Gene Name | |
| Organism | Rhizopus azygosporus (Rhizopus microsporus var. azygosporus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Fungi incertae sedis Mucoromycota Mucoromycotina Mucoromycetes Mucorales (pin molds) Mucorineae Rhizopodaceae Rhizopus Rhizopus azygosporus (Rhizopus microsporus var. azygosporus) |
| Enzyme Sequence | AGVGTVP |
| Enzyme Length | 7 |
| Uniprot Accession Number | C0HLM4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.; EC=3.4.23.21; Evidence={ECO:0000269|PubMed:31219401}; |
| DNA Binding | |
| EC Number | 3.4.23.21 |
| Enzyme Function | |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is between 45-50 degrees Celsius with hemoglobin as substrate. Loses 50% of its activity at 60 degrees Celsius. {ECO:0000269|PubMed:31219401}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7 with hemoglobin as substrate. {ECO:0000269|PubMed:31219401}; |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Non-terminal residue (2) |
| Keywords | Aspartyl protease;Direct protein sequencing;Hydrolase;Protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 600 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |