| IED ID | IndEnz0002004490 |
| Enzyme Type ID | protease004490 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase calypso EC 3.4.19.12 BAP1 homolog |
| Gene Name | calypso CPIJ001439 |
| Organism | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Culicoidea Culicidae (mosquitos) Culicinae Culicini Culex Culex Culex pipiens complex Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
| Enzyme Sequence | MPVDINRLTDGWLELESDPGLFTLLLEDFGVKGVQVEEIYDLQKTIEGPVFGFIFLFRWIEERRARRKIVETTTEMYVKDEEAVNSIFFAHQVVPNSCATHALLSVLLNCSDIDLGTTLSRLKVHTKGMCPDNKGWAIGNTPELACAHNSHAMPQARRRMDRNSGVSTGRFTGEAFHFVSFCPINGHLFELDGLKPFPMDHGPWGEKEDWTDKFRRVMSDRLGISTDRRIAITHKLKMLRTNQTIVSAALEKLLKSKQLESRSQAEIRETVDKIKKEEQESTVKLSSEYSQLLEMHEKDEPAVAMSKELESLVSLNSSSDSVEIIGETEIKKENPPPSPPPAFIGAGTFSPKDLLSLLKNLESEINITEQHLCDENEKRAMFKVDDCRRTHNYDEFICTFLSMLAYQGELGDLVTQHLVTSRKPSLGGVQNSGSRGVVRNYNKKSTTNGSSPKTPSSKRRRGRTKYRKRK |
| Enzyme Length | 470 |
| Uniprot Accession Number | B0W2R4 |
| Absorption | |
| Active Site | ACT_SITE 98; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 177; /note=Proton donor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Region (1); Site (1) |
| Keywords | Chromatin regulator;Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to PcG response elements (PREs). {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 53,180 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |