| IED ID | IndEnz0002004551 |
| Enzyme Type ID | protease004551 |
| Protein Name |
Kazal-type serine protease inhibitor domain-containing protein 1 Bone and odontoblast-expressed protein 1 Insulin-like growth factor-binding-related protein 10 IGFBP-rP10 IGFBP-related protein 10 Insulin-like growth factor-binding-related protein 4 |
| Gene Name | Kazald1 Bono1 Igfbprp10 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MPRVFTGLPANYAAPTLALSLLLPLLLVVWTQLPVSARPSTGPDYLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSANFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLTVLTPEQLNATGFSQLQSRSLFPEEEEEAESEELGDYY |
| Enzyme Length | 313 |
| Uniprot Accession Number | Q8BJ66 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly. {ECO:0000269|PubMed:15555553, ECO:0000269|PubMed:18757743}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Domain (3); Glycosylation (3); Region (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Developmental protein;Differentiation;Disulfide bond;Extracellular matrix;Glycoprotein;Immunoglobulin domain;Osteogenesis;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Up-regulated during the early phase of the bone regeneration. Up-regulated by BMP2 during osteoblast differentiation. {ECO:0000269|PubMed:15555553}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18757743}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..37; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14610273; 16813524; 20562862; 21386911; 21677750; 23031221; 32274496; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,272 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |