| IED ID | IndEnz0002004592 |
| Enzyme Type ID | protease004592 |
| Protein Name |
Deubiquitinase and deneddylase Dub1 ChlaDub1 EC 3.4.22.- |
| Gene Name | cdu1 CTL0247 |
| Organism | Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) |
| Taxonomic Lineage | cellular organisms Bacteria PVC group Chlamydiae Chlamydiia Chlamydiales Chlamydiaceae Chlamydia/Chlamydophila group Chlamydia Chlamydia trachomatis Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) |
| Enzyme Sequence | MLSPTNSTSKTAPVPPRDSSKPVLISEEPRNQLLQKVARTALAVLLVVVTLGLILLFYSFSDLQSFPWCCQTHPSTKEQPTISIPVPLPSPPLAVPRPSTPPPPVISRPSTPSAPKPSTPPPLLPKAPKPVKTQEDLLPLVPEQVFVEMYEDMARRQTIEALVPAWDSDIIFKCLCYFHTLYPGLIPLETFPPATIFNFKQKIISILEDKKAVLRGEPIKGPLPICCSKENYRRHLQRTTLLPVFMWYHPTPKTLSDTMQTMKQLAIKGSVGASHWLLVIVDIQARRLVYFDSLYNYVMPPENMKKELQSFAQQLDQVYPAYDSKKFSVKIAAKEVIQRGSGSSCGAWCCQFLHWYLKDPLTDALNDLPVDSVERHENLASFVQACEAAVQDLPELSWPEA |
| Enzyme Length | 401 |
| Uniprot Accession Number | B0B9A0 |
| Absorption | |
| Active Site | ACT_SITE 275; /evidence=ECO:0000255; ACT_SITE 292; /evidence=ECO:0000255; ACT_SITE 345; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities (By similarity). Impairs ubiquitination and degradation of NF-kappa-B inhibitor alpha (NFKBIA), thereby preventing NF-kappa-B activation. {ECO:0000250, ECO:0000269|PubMed:18503636}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (9); Chain (1); Compositional bias (2); Helix (10); Region (2); Transmembrane (1); Turn (2) |
| Keywords | 3D-structure;Hydrolase;Membrane;Protease;Secreted;Thiol protease;Transmembrane;Transmembrane helix;Ubl conjugation pathway;Virulence |
| Interact With | |
| Induction | INDUCTION: Expressed late in the infectious cycle. {ECO:0000269|PubMed:18503636}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18503636}. Host cell {ECO:0000269|PubMed:18503636}. Membrane {ECO:0000269|PubMed:18503636}; Single-pass membrane protein {ECO:0000269|PubMed:18503636}. Note=Secreted, and delivered into the host cell. Located predominantly on the plasma membrane and to a lesser extent on intracellular membranes, especially the host cell nuclear envelope. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (7) |
| Cross Reference PDB | 5B5Q; 5HAG; 6FDK; 6FDQ; 6FDU; 6GZS; 6GZT; |
| Mapped Pubmed ID | 27425412; 28347402; 30028574; 30397340; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,977 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |