| IED ID | IndEnz0002004595 |
| Enzyme Type ID | protease004595 |
| Protein Name |
Derlin-1 Degradation in endoplasmic reticulum protein 1 Der1-like protein 1 |
| Gene Name | Derl1 Der1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ |
| Enzyme Length | 251 |
| Uniprot Accession Number | Q99J56 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane. This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. {ECO:0000250|UniProtKB:Q9BUN8}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Initiator methionine (1); Modified residue (4); Motif (1); Region (1); Sequence conflict (3); Topological domain (7); Transmembrane (6) |
| Keywords | Acetylation;Endoplasmic reticulum;Membrane;Phosphoprotein;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport;Unfolded protein response |
| Interact With | |
| Induction | INDUCTION: Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). {ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}. |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BUN8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BUN8}. |
| Modified Residue | MOD_RES 2; /note=N-acetylserine; /evidence=ECO:0000250|UniProtKB:Q9BUN8; MOD_RES 201; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:21183079; MOD_RES 202; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q9BUN8; MOD_RES 226; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BUN8 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 15215855; 15215856; 16055502; 18519638; 18554416; 18799693; 19509052; 21267068; 22479592; 23233672; 26692333; 32858914; 34355142; |
| Motif | MOTIF 241..248; /note=SHP-box; /evidence=ECO:0000250|UniProtKB:Q9BUN8 |
| Gene Encoded By | |
| Mass | 28,835 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |