| IED ID | IndEnz0002004598 |
| Enzyme Type ID | protease004598 |
| Protein Name |
CUB domain-containing protein 1 Membrane glycoprotein gp140 Subtractive immunization M plus HEp3-associated 135 kDa protein SIMA135 Transmembrane and associated with src kinases CD antigen CD318 |
| Gene Name | CDCP1 TRASK UNQ2486/PRO5773 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAGLNCGVSIALLGVLLLGAARLPRGAEAFEIALPRESNITVLIKLGTPTLLAKPCYIVISKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIEPRPVKQSRKFVPGCFVCLESRTCSSNLTLTSGSKHKISFLCDDLTRLWMNVEKTISCTDHRYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSFSYLVASAIPSQDLYFGSFCPGGSIKQIQVKQNISVTLRTFAPSFQQEASRQGLTVSFIPYFKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQTGRAFMIIQEQRTRAEEIFSLDEDVLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLTPRTVDLTVILIAAVGGGVLLLSALGLIICCVKKKKKKTNKGPAVGIYNDNINTEMPRQPKKFQKGRKDNDSHVYAVIEDTMVYGHLLQDSSGSFLQPEVDTYRPFQGTMGVCPPSPPTICSRAPTAKLATEEPPPRSPPESESEPYTFSHPNNGDVSSKDTDIPLLNTQEPMEPAE |
| Enzyme Length | 836 |
| Uniprot Accession Number | Q9H5V8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Chain (1); Compositional bias (1); Disulfide bond (1); Domain (1); Erroneous initiation (1); Glycosylation (7); Modified residue (1); Mutagenesis (2); Natural variant (3); Region (1); Sequence conflict (6); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Cell membrane;Direct protein sequencing;Disulfide bond;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Secreted;Signal;Transmembrane;Transmembrane helix |
| Interact With | O00560; P12931; P07947 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted. |
| Modified Residue | MOD_RES 734; /note=Phosphotyrosine; /evidence=ECO:0000269|PubMed:14739293 |
| Post Translational Modification | PTM: Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. {ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:14739293, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:8647901}.; PTM: N-glycosylated. {ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:14739293, ECO:0000269|PubMed:16007225}.; PTM: A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease. |
| Signal Peptide | SIGNAL 1..29; /evidence="ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:16007225" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15174051; 15657067; 16926850; 17785447; 18269919; 18467693; 18483259; 18483744; 19077003; 19318475; 19463016; 19671673; 19916495; 20372833; 20501830; 20551327; 21189288; 21220330; 21233420; 21490433; 21559459; 21617380; 21706059; 21725358; 21812858; 21994943; 22315226; 22457534; 23208492; 23300860; 23378636; 23439492; 23510015; 23747337; 24384474; 24681947; 24849519; 24939643; 25275584; 25301083; 25416956; 25728678; 25775948; 25820997; 25876044; 25892239; 25893298; 26307391; 26497208; 26553452; 26876198; 26956052; 27495374; 27626701; 27685922; 28537886; 28739932; 29351434; 29433983; 29447112; 29511352; 29574172; 29792166; 30396925; 31364124; 31471585; 31965270; 32226543; 32250342; 32983115; 33060289; 33260155; 33267838; 33674603; 33859413; |
| Motif | |
| Gene Encoded By | |
| Mass | 92,932 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |