| IED ID | IndEnz0002004619 |
| Enzyme Type ID | protease004619 |
| Protein Name |
CAAX prenyl protease 2 EC 3.4.-.- Farnesylated proteins-converting enzyme 2 FACE-2 Prenyl protein-specific endoprotease 2 Protein severas |
| Gene Name | Sras CG4852 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MKNLSETEAEVTMQENVVHESLPQIPVATSVSCCFVLAVLYVGSLYIWSTKHNRDHPTTVKRRFASVSMVMLAAPFFVYFFSSPELLSRVPFPKLLGLRLEGLWQAVVIPYSLTVLLFLGPIFVNMQNESVRSYFDLDYWRGSFGSIIWVRNHVIAPLSEEFVFRACMMPLILQSFSPLVAVFITPLFFGVAHLHHIAERLSLGVELSTALLIGLFQFIYTTLFGFYSAFLFARTGHVMAPILVHAFCNHMGLPDLQDLWQQDLWRRVVAIILYLAGFVGWMFLVPLATDPSIYDNTLYWNA |
| Enzyme Length | 302 |
| Uniprot Accession Number | Q9U1H8 |
| Absorption | |
| Active Site | ACT_SITE 160; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:Q6LZY8; ACT_SITE 193; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:Q6LZY8 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. {ECO:0000250|UniProtKB:Q9Y256}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous initiation (1); Sequence conflict (3); Site (2); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y256}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y256}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11343912; 12865422; 14525933; 17785192; 19079254; 19213920; 20220848; 20371351; 23071443; 25312911; 25933381; 26370122; 27172210; 28017617; 31722958; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,415 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |