| IED ID | IndEnz0002004698 |
| Enzyme Type ID | protease004698 |
| Protein Name |
Probable aspartic-type endopeptidase CTSD EC 3.4.23.- |
| Gene Name | CTSD TRV_03534 |
| Organism | Trichophyton verrucosum (strain HKI 0517) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton verrucosum (Cattle ringworm fungus) Trichophyton verrucosum (strain HKI 0517) |
| Enzyme Sequence | MQFLWLCLLSAVTLQFTGTLAFYPIKLPDFTKGLVSNHGSIDRRFFTFPGLYKHAHTGSTTLNIRRGPSNYRRDNNYPAQIASPPTAPNTLGINNDGYDFSYFSEVKVGSEGQKMWMLIDTGASGTWVFGSDCTSKACGRHNTFGKEDSKTIKVTDEKWGVTYGTGKVSGVIVNDTMSFAGFELVTPFGSASTASDDFLNYPMDGILGIGPQDPNAKTPTVVQLLMQQKLLKSNVIGINLQRASEGATDGQITFGDIDKSKFSGELIYSNVVPDGYQWEIAMDDLIMDGKSLNLKGRTGIIDTGTSFLILPPADADLIHSMIPQANKGSGFYTLPCSTKVDIKLSIGGVEYTIQPDDYVGNETATKGTCNSLIVGRQILGPKQWLVGDVFLKNVYSVFDFDKNRVGLAARKYAGTKNPPSSTPSPGMFLLHAILCPKTISVLMLHIDPTSNKAPSGGSPGLPAESGSDSTTNGEATNGATSSPNSSSSVLTPTWLTLAVFFAIGSSLWS |
| Enzyme Length | 509 |
| Uniprot Accession Number | D4D8U6 |
| Absorption | |
| Active Site | ACT_SITE 120; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 302; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable GPI-anchored aspartic-type endopeptidase which contributes to virulence. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Glycosylation (3); Lipidation (1); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Cell membrane;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Signal;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 54,631 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |