| IED ID | IndEnz0002004709 |
| Enzyme Type ID | protease004709 |
| Protein Name |
Bradykinin-potentiating peptide 10e BPP-10e |
| Gene Name | |
| Organism | Bothrops cotiara (Cotiara) (Rhinocerophis cotiara) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops cotiara (Cotiara) (Rhinocerophis cotiara) |
| Enzyme Sequence | QNWPSPKVPP |
| Enzyme Length | 10 |
| Uniprot Accession Number | P0DJK3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: This peptide evokes transient hypotension (-11 mmHg) similar to that evoked by 0,5 ug of bradykinin, when injected alone into rats. It has a high bradykinin-potentiating effect (113%), when 60 nmol of BPP-10e are coinjected with 0.5 ug of bradykinin into rats. It inhibits angiotensin converting enzyme (ACE) activity with a K(i)app of 16.21 uM. {ECO:0000269|PubMed:22869554}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Modified residue (1); Peptide (1); Sequence uncertainty (1) |
| Keywords | Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:22869554 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,149 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |