| IED ID | IndEnz0002004724 |
| Enzyme Type ID | protease004724 |
| Protein Name |
COP9 signalosome complex subunit 5 EC 3.4.-.- |
| Gene Name | RRI1 CSN5 CAGL0G05676g |
| Organism | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Nakaseomyces Nakaseomyces/Candida clade Candida glabrata (Yeast) (Torulopsis glabrata) Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
| Enzyme Sequence | MDDFPSLNVSDLESKLLDYNIRDYEVQNSKHKNNIAGNEKESIDQLSLLNQVCSLKNRKAIDSTKNSPLFYQNVLLSKLACSKILCHATKGGNIEVMGMLLGNVIGNTFVIFDCFELPVEGTETMVNAHMESYEYMVQFYHEMVERSYTRNEENLNIIGWYHSHPGYDCWLSNIDMQTQSLNQQHQDPYLAIVVDPHKSKNDQKVRIGSFRTYQDQNDDTNFYELNTTVFDSELNKLENPLSVKIPFNSIESRNLESNYLQKLSETVKQWRNFKIMEKIENTAHTEDTTTNKSISTPGRIIQTAHEFAFAATSNGNGSRVNIMRSNSVSSIGSSSDIEMEDRNCSAFDSVASSINTIADPSRTSSIHTQMNNQNNQQERNSPKRPHILPAIQSSRYGVIFEGKDRPENKNFNIRTASAQDAFESKCIDDFHESLKNDYLTQKEILLRLKLRQYYRLRMYRDMFSK |
| Enzyme Length | 465 |
| Uniprot Accession Number | Q6FT36 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (1); Metal binding (3); Motif (1); Region (1) |
| Keywords | Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Nucleus;Protease;Reference proteome;Signalosome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 162..175; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 53,521 |
| Kinetics | |
| Metal Binding | METAL 162; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 164; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 175; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda |