| IED ID | IndEnz0002004737 |
| Enzyme Type ID | protease004737 |
| Protein Name |
Cathepsin K EC 3.4.22.38 JTAP-1 |
| Gene Name | CTSK |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MLRLHWLALLVLLLPMAAAQLRPEPELDAQWDLWKRTIQKAVQRQGGRNVPEVDLGEEPEVHRCPQRGARLGKHSFQLAMNYLGDMTSEEVVRTMTGLRVPRSRPRPNGTLYVPDWSSRAPAAVDWRRKGYVTPVKDQGQCGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVYCVSNNNGCGGGYMTNAFEYVRLNRGIDSEDAYPYIGQDESCMYSPTGKAAKCRGYREIPEDNEKALKRAVARIGPVSVGIDASLPSFQFYSRGVYYDTGCNPENINHAVLAVGYGAQKGTKHWIIKNSWGTEWGNKGYVLLARNMKQTCGIANLASFPKM |
| Enzyme Length | 334 |
| Uniprot Accession Number | Q90686 |
| Absorption | |
| Active Site | ACT_SITE 144; /evidence=ECO:0000250; ACT_SITE 281; /evidence=ECO:0000250; ACT_SITE 301; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.; EC=3.4.22.38; Evidence={ECO:0000250|UniProtKB:P43235}; |
| DNA Binding | |
| EC Number | 3.4.22.38 |
| Enzyme Function | FUNCTION: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). {ECO:0000250|UniProtKB:P43235}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (1); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | INDUCTION: Up-regulated in response to V-Jun induced cell transformation. {ECO:0000269|PubMed:8552384}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 19661463; |
| Motif | |
| Gene Encoded By | |
| Mass | 37,219 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |