| IED ID | IndEnz0002004749 |
| Enzyme Type ID | protease004749 |
| Protein Name |
Rhizopuspepsin-2 EC 3.4.23.21 Aspartate protease |
| Gene Name | |
| Organism | Rhizopus niveus |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Fungi incertae sedis Mucoromycota Mucoromycotina Mucoromycetes Mucorales (pin molds) Mucorineae Rhizopodaceae Rhizopus Rhizopus niveus |
| Enzyme Sequence | MKLTLISSCVALAFMALATEAAPSGKKLSIPLTKNTNYKPSAKNAIQKALAKYHRFRTTSSSNSTSTEGTGSVPVTDYYNDIEYYGKVTVGTPGVTLKLDFDTGSSDLWFASTLCTNCGSSQTKYNPNQSSTYAKDGRTWSISYGDGSSASGILGTDTVTLGGLKITKQTIELAKREATSFQSGPSYGLLGLGFDTITTVRGVKTPVDNLISQGLISKPIFGVYLGKESNGGGGEYIFGGYDSSKYSGSLTTIPVDNSNGWYGITIKGTTIGSSKVSSSFSAILDTGTTLLILPNNVASAVARSYGASDNGDGTYTIDCDTSSFKPLVFSIGSSTFEVPADSLVFEQDGSTCYAGFGYGDYDFAIFGDVFLKNNYVVFNQEVPEVQIAPIA |
| Enzyme Length | 391 |
| Uniprot Accession Number | P43231 |
| Absorption | |
| Active Site | ACT_SITE 102; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 285; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.; EC=3.4.23.21; |
| DNA Binding | |
| EC Number | 3.4.23.21 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (2); Domain (1); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Disulfide bond;Hydrolase;Protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 41,234 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |