| IED ID | IndEnz0002004767 |
| Enzyme Type ID | protease004767 |
| Protein Name |
Calpain-type cysteine protease DEK1 EC 3.4.22.- Phytocalpain DEK1 Protein DEFECTIVE KERNEL 1 ZmDEK1 |
| Gene Name | DEK1 |
| Organism | Zea mays (Maize) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae PACMAD clade Panicoideae Andropogonodae Andropogoneae Tripsacinae Zea Zea mays (Maize) |
| Enzyme Sequence | MEGEGHHGVVLACSICGFLFAVLSPFSFWVLWAVNWRPWRLYSWIYARKWPTYVQGPQLSTLCSLLTLCAWLVVISPIAVLLVWGSVLIALMERNIIGLAVIMAGVALLLSFYSIMLWWRTQWQSSEAVAYLLLLAVCLLCAYDFCAIYVTAGASASELNSPSGFFFGVSVISLAINMLFICKILFNVSGFDVDEYVRRSYKFAYSDCVEVAPVSCSPEPPDPSELYMTKSSRVKHLGLLYISSLLVLVGYSILYGLTSKEARWLGALTSVAVVILDWNLGLCSFRFELLKSRMIVLFVAGTSRAFLVSFGVHYWYLGHCISYAFVASVLLSAAVSSWLSISNPSVARIDALRSTVIKLREGFRRKGQNSSSNSSEGCGSSVKRSSGSVEAGQNGNAMDSMYRSNSQSDGVNWSSIPFDRSNSCQEGRSSDKNIDSARASLAHRSNSCLSAVQDSETAVVSVDRHGDPITSLVCSSSGLESHGCEPSGSATTSGNQQLLDLNLAAIFQDRLNDPRISSMLKKNGGLGDVELANLLQDKGLDPNFSYMLKDKVMDPRILALLQRSSLDADREHQDDVDVTATDSDRLDTTIANQISLSEELRRSGLEKWLNISRLIFHHLAGSPIRAFIVFTVMFIIETATVAIYRPETIKVINATHEQFEFGFSILLLSPVVCSIMAFIWSLRAEEMLMTSKPQKYGFIAWLLSTCVGLFLSFLSKSSVILGLSLTVPLMVACLSFAVPIWIRNGYSFWIPGREFANRENVSQAPGEKERALFVITIAVFTASIIGLGAIVSAKPLDALGYKGWDADKNSSYSPYATSMYLGWALSSTIAVITTGLIPIVAWFATYRFSPSSAICVGLFATVLVSFCGASYWGVVNSREDGVPLKADFLAALLPLLCIPAFFSLFTGLYKWKDDDWKISRGVYLFVGMGMLLLFGAVAAVIVTIRPWTVGVACLVAILFLVFVIGVIHYWTSNNFYLTRTQMLLVCSIAFLLALAAFLMGLFHGKPFVGASIGYFSFIFLLTGRALTVLLSPPIVVYSPRVLPVYVYDAHADSAKNVSYAFLILYGIALATEVWGVIASLIMNPPFVGAGVSATTLVIAFSFAVSRPCLTLKMMEDAVHFLSKDTVVQAMSRSANKTRNAISGTYSAPQRSASSAALLVGDPALTLDRAGNFVLPRADVMKLRDRLRNEEIAAGSFLCGVKDCLLICPQSLSNIDYRRNMCAHARILALEEAIDTEWVYMWDKFGGYLLLLLGLTAKAEQIQDEVRLRLFLDSIGLSDLSAKEIKKWMPEDRRQFELIQESYIREKEMEEEALMQRREEEGKGRERRRALLEREERKWKELEISLLSSIPNTGSRDAAAMAAAVRAVGGDSALEDSFARDRVSSIANHIRKAQLARRAEQTGIPGTICILDDEPRSTGRHCGELDLCLCQSQKVTLSIAVMVQPVSGPVCLFGSEFQKVCWEILVAGSEQGMEAGQVGLRLVTKGERMTTVAKEWNIGASSIADGRWHLVTVTLDADLGEATSFIDGVYDGYQNGLPLPTDNGIWEPGTDIWVGARPPMDLDAFGRSDSEGSDSKMQIMDAFLWGRCLSEDEVTVLHTAMSPAEYGFFDLAPGDAWHGSYSARVDDWESEEAYELYDQGDVEWDGQYSSGRKRPVHDAVAIDLDSFARRPRKPRFETRDEVNQRMLSVERAVRDALIAKGERNFTDQEFPPEDRSLFVDPMNPPLKLQVVSEWMRPSDIAKDISISCQPCLFSGSVNSSDVCQGRLGDCWFLSAVAVLTEMSRISEVIITPEYNDEGIYTVRFCIQGEWVAVVVDDWIPCESPGKPAFATSRKQNELWVSILEKAYAKLHGSYEALEGGLVQDALVDLTGGAGEEIDMRSPQAQLDLASGRLWSQLLHFKQEGFLLGAGSPSGSDAHISSSGIVQGHAYSILQVREVDGHKLIQIRNPWANEVEWNGPWSDSSPEWTERMKHKLMHVPQSKNGVFWMSWQDFQIHFRSIYVCRVYPPEMRYSVHGQWRGYNAGGCQDYDSWHQNPQYRLRVTGRDALYPVHVFITLTQGVGFSRKTNGFRNYQSSHDSSMFYIGMRILKTQGCRAAYNIYMHESAGGTDYVNSREISCELVLDPYPKGYTIVPTTIHPGEEAPFVLSVFSKASIRLEAV |
| Enzyme Length | 2159 |
| Uniprot Accession Number | Q8RVL1 |
| Absorption | |
| Active Site | ACT_SITE 1769; /evidence=ECO:0000250; ACT_SITE 1927; /evidence=ECO:0000250; ACT_SITE 1947; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Essential protease involved in epiderm development. Required for aleurone cell development in the endosperm probably by maintaining and restricting the aleurone and embryonic epidermal L1 cell-layer fates as well as meristems organization. Involved in the maintenance of adaxial/abaxial axis information in developing leaves, probably by regulating cell proliferation and expansion. Does not need calcium ions to be active. {ECO:0000269|PubMed:11929961, ECO:0000269|PubMed:12824178, ECO:0000269|PubMed:17933905}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Compositional bias (1); Domain (2); Modified residue (3); Mutagenesis (1); Propeptide (1); Region (1); Sequence conflict (5); Signal peptide (1); Topological domain (22); Transmembrane (21) |
| Keywords | Alternative splicing;Cell membrane;Cytoplasm;Developmental protein;Endoplasmic reticulum;Endosome;Hydrolase;Membrane;Phosphoprotein;Protease;Reference proteome;Repeat;Signal;Thiol protease;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:17933905}; Multi-pass membrane protein {ECO:0000269|PubMed:17933905}. Endosome membrane {ECO:0000269|PubMed:17933905}; Multi-pass membrane protein {ECO:0000269|PubMed:17933905}. |
| Modified Residue | MOD_RES 1371; /note=Phosphoserine; /evidence=ECO:0000250; MOD_RES 1376; /note=Phosphoserine; /evidence=ECO:0000250; MOD_RES 1665; /note=Phosphoserine; /evidence=ECO:0000250 |
| Post Translational Modification | PTM: Autocatalytic proteolytic cleavage leading to the production of mainly cytoplasmic localized subproducts of about 85 and 120 kDa. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10952901; 21617032; |
| Motif | |
| Gene Encoded By | |
| Mass | 239,106 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |