| IED ID | IndEnz0002004771 |
| Enzyme Type ID | protease004771 |
| Protein Name |
T-cell-specific surface glycoprotein CD28 TP44 CD antigen CD28 |
| Gene Name | CD28 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS |
| Enzyme Length | 220 |
| Uniprot Accession Number | P10747 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). {ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:8617933}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (7); Beta strand (11); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (5); Helix (1); Modified residue (3); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | 3D-structure;Alternative splicing;Disulfide bond;Glycoprotein;Immunoglobulin domain;Membrane;Phosphoprotein;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | P27986; P01552 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface {ECO:0000269|PubMed:15067037}. |
| Modified Residue | MOD_RES 189; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:19690332; MOD_RES 191; /note=Phosphotyrosine; /evidence=ECO:0007744|PubMed:19690332; MOD_RES 209; /note=Phosphotyrosine; /evidence=ECO:0007744|PubMed:15144186 |
| Post Translational Modification | PTM: CD40LG induces tyrosine phosphorylation of isoform 3. {ECO:0000269|PubMed:15067037}. |
| Signal Peptide | SIGNAL 1..18 |
| Structure 3D | X-ray crystallography (6) |
| Cross Reference PDB | 1YJD; 3WA4; 5AUL; 5GJH; 5GJI; 6O8D; |
| Mapped Pubmed ID | 10792419; 10820259; 10849438; 11096256; 11285224; 11500828; 11685455; 11713465; 11714771; 11826026; 11826754; 11830501; 11884439; 11932928; 11958588; 11986289; 12036883; 12050373; 12059054; 12077252; 12097397; 12121283; 12121659; 12195013; 12195015; 12207353; 12297341; 12324461; 12377947; 12393716; 12482386; 12506015; 12626540; 12660731; 12670391; 12670394; 12842899; 12864988; 12928366; 12952926; 12963692; 14550257; 14642527; 14697933; 14975605; 14984593; 15019278; 15079071; 15194762; 15214045; 15280538; 15284240; 15353589; 15494485; 15834429; 15886116; 15953005; 16005527; 16112024; 16136471; 16237465; 16339520; 16493040; 16564528; 16638702; 16647110; 16698688; 16708397; 16801532; 16818765; 16969077; 17015696; 17060905; 17119120; 17197413; 17237383; 17242350; 17284227; 17311991; 17467674; 17703412; 17785788; 17804530; 17878327; 17878391; 17899554; 18097023; 18162511; 18174230; 18211507; 18246813; 18295596; 18337305; 18389481; 18390701; 18396212; 18566382; 18566447; 18573819; 18606717; 18617642; 18625635; 18680513; 18684977; 18751903; 18754654; 18802089; 18829560; 18989760; 19086656; 19109140; 19202444; 19203082; 19211796; 19214786; 19217084; 19258923; 19284445; 19299722; 19333372; 19380781; 19411071; 19573080; 19644473; 19672595; 19735272; 19752224; 19773279; 19805105; 19824886; 19852851; 19857736; 19898481; 19913589; 19959217; 20113255; 20126467; 20137575; 20140740; 20190752; 20228198; 20237496; 20331378; 20368329; 20371478; 20390280; 20433886; 20435510; 20470888; 20477885; 20503287; 20522708; 20568250; 20713702; 20716621; 20814620; 20842443; 20844584; 20846283; 20858890; 20863851; 20962715; 21048031; 21160481; 21268019; 21277899; 21291098; 21317208; 21324454; 21356099; 21368164; 21384512; 21508506; 21530327; 21540550; 21544637; 21668414; 21669243; 21677403; 21715687; 21827948; 21931534; 21964608; 21976531; 21982860; 22013130; 22094905; 22188813; 22230325; 22385243; 22503210; 22579879; 22588880; 22732586; 22783574; 22802530; 22917707; 23133541; 23163888; 23411043; 23456842; 23470321; 23483974; 23532603; 23589613; 23747721; 23966623; 24043548; 24057239; 24103478; 24163161; 24347824; 24368148; 24374661; 24412596; 24548923; 24564845; 24726754; 24782505; 24951814; 25013781; 25382658; 25448703; 25482073; 25497975; 25534869; 25539813; 25787182; 25829543; 25998553; 26041540; 26043137; 26215444; 26277688; 26375412; 26403483; 26405154; 26408701; 26719098; 26819049; 26860071; 26950734; 27108398; 27125674; 27314219; 27381613; 27460989; 27488439; 27530312; 27647348; 27878564; 27904907; 27927989; 28031007; 28087292; 28102614; 28392336; 28550199; 28673752; 28711152; 29042364; 29089469; 29305966; 29371709; 29697355; 29992636; 30117787; 30197180; 30251665; 30279692; 30362552; 30425092; 30867406; 31114583; 31167920; 31212712; 31235485; 31292214; 31400229; 31826563; 31907973; 31961925; 32446033; 32579940; 32765524; 32814710; 32875738; 32935413; 32967633; 33097290; 33169838; 33178223; 33205842; 33281809; 33363541; 33803858; 33958973; 34017081; 34149691; 34214472; 34738707; 7568038; 7584133; 7737275; 7807015; 8146197; 8183372; 8609386; 8621607; 8649453; 8657148; 8946678; 8990121; 8992971; 9032261; 9417079; 9438848; 9694876; 9822663; 9973466; |
| Motif | |
| Gene Encoded By | |
| Mass | 25,066 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |