| IED ID | IndEnz0002004775 |
| Enzyme Type ID | protease004775 |
| Protein Name |
Complement factor I EC 3.4.21.45 C3B/C4B inactivator Cleaved into: Complement factor I heavy chain; Complement factor I light chain |
| Gene Name | CFI |
| Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Ponginae Pongo Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Enzyme Sequence | MKLLHVFLLFLCFHLSFCKVTYTSQEDLVEKKCLAKKHTHLSCNKVFCQPWQICIEGTCICKLPYQCPKNGTTVCATNGRSFPTYCQQKSLECLRPGTKFLNNGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSNLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDLADVVCYTQKADSPTNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKSFHCKSGVCIPSQYRCNGEVDCITGEDEVGCEGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRRHIRRKRIVGGKRAQLGDLPWQVGIKDASGITCGGIYIGGCWILTAAHCLRASKTHHYQIWTTVVDWIHPDRKRIVIEYVDRIIFHENYNAGTYQNDIALMEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNEKVFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV |
| Enzyme Length | 583 |
| Uniprot Accession Number | Q5R5A4 |
| Absorption | |
| Active Site | ACT_SITE 380; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 429; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 525; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 239..253; /note=1; /evidence=ECO:0000250; CA_BIND 276..290; /note=2; /evidence=ECO:0000250 |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.; EC=3.4.21.45; |
| DNA Binding | |
| EC Number | 3.4.21.45 |
| Enzyme Function | FUNCTION: Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Calcium binding (2); Chain (3); Disulfide bond (19); Domain (5); Glycosylation (7); Signal peptide (1) |
| Keywords | Calcium;Cleavage on pair of basic residues;Complement pathway;Disulfide bond;Glycoprotein;Hydrolase;Immunity;Innate immunity;Metal-binding;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 65,620 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |