| IED ID | IndEnz0002004857 |
| Enzyme Type ID | protease004857 |
| Protein Name |
Pro-apoptotic serine protease nma111 EC 3.4.21.- |
| Gene Name | nma111 AO090103000320 |
| Organism | Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Circumdati Aspergillus oryzae (Yellow koji mold) Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
| Enzyme Sequence | MDLNGDAGAKRKRSSIVPAERPAKHLKPESSALTPGDSTPANGTVYDIEDEDDASRLLPIGPAQADSPEWQATIEEVVKSVVSIHFCQTCSFDTELSMSSQATGFVVDAERGYILTNRHVVCPGPFWGYCIFDNHEECDVRPVYRDPVHDFGILKFDPKAIRYMNLTELKLQPDAARVGSEIRVVGNDAGEKLSILSGVISRLDRNAPEYGEGYSDFNTNYIQAAAAASGGSSGSPVVNIDGHAIALQAGGRADGAATDYFLPLDRPLRALECIRRGEPVTRGTIQTQWILKPFDECRRLGLTPEWEATVRKAAPTETSMLVAEIILPEGPADGKLEEGDVLLQVNGELLTQFIRLDDILDSSVGQTVRLLVQRGGQDVEIECQVGDLHAITPDRFVTVAGGTFHDLSYQQSRLYAIATRGVYVCEAAGSFKLENTLSGWLIDSVDKRPTRNLDEFVEVMKTIPDRSRVVISYRHIRDLHTRGTSIVYIDRHWHPKMRLAVRNDETGLWDFSDLADALPALPPVPRKADFIQLDGVSQPAASEIVRSFVRVSCTMPLKLDGYPQAKKTGFGLVVDAEKGLVVVSRAIVPYDLCDINITVADSIIVNAKVVFLHPLQNYTIIQYDPSLVQAPVQSAKLSTEYIKQGQDTIFVGFNQNFRIVVAKTAVTDITTVSIPANASAPRYRAINLDAVTVDTGLSGQCSNGVLIGEDGVVQALWLNYLGERTPSSHKDVEYHLGFATPSLLPVVSKIQQGVMPELRILNMESYVVQMSQARIMGVSEEWIEKVTQANPSRHQLFMVRKVDCPPAGFDNMADTFQEGDILLTLDGQLITRVSELDVMYDKEFLEALIVRNGQEMRIQVPTVPTADLETDRAVVFCGAVLQKPHHAVRQQISKLHSEIYVSARSRGSPSYQYGLSPTNFITAVNGVPTPDLDRFVKEVSKIPDNTYFRLRAVTFDNVPWVVTMKKNDHYFPMSEYLKDPSQPCGWRTVSHNKSKHKDGIAPDAANLNPDAMEQGYDGASDIEPEAE |
| Enzyme Length | 1027 |
| Uniprot Accession Number | Q2TYB1 |
| Absorption | |
| Active Site | ACT_SITE 119; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 150; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 232; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Nuclear serine protease which mediates apoptosis. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Domain (2); Region (3) |
| Keywords | Apoptosis;Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 113,315 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |