| IED ID | IndEnz0002004881 |
| Enzyme Type ID | protease004881 |
| Protein Name |
Carboxypeptidase Z CPZ cCPZ EC 3.4.17.- |
| Gene Name | CPZ |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MVPSLLLLLTGLFRATEPAPRCETGQETLGQCQTAQKAKCVDISLSSCTDVTYTQTMYPNFLDQKSREVIEYSSEYILISVLHNLLQGECNPDLRLLGCSVLAPQCEKDKVIKPCRHVCENLKKNCLSAFDAIDMAWPYFLDCDRFFAGEEEGCFDPLAKLRGEVAVEEDLPSDFPATFIQFKHHSYSQMVSTLKKTASRCSHIATTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLYTLRSICVQKYLLGNPRIQTLINNTRIHLLPSLNPDGYERAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHIPIPQSYWWGKVAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKEFSPTPDEKMFKMLAKAYADAHPVISDRSEHRCGGNFVKRGGIINGAEWYSFTGGMADFNYLHTNCFEVTVEVGCEKFPLEEELFTIWHENRDALLNYMEMVHRGIKGIVSDKFGNPIKNARISVRGIQHDITTAADGDYWRLLPPGTYIVTAQAMGYTKVMKRVTLPIKMKRAGRVDFVLRPIEIWPNKLLRRPMEDMYDQYDPLELFDPHAQHAQARGGSQQVREKPWWWSYFSSLDLHKPLWLLKQH |
| Enzyme Length | 647 |
| Uniprot Accession Number | Q8QGP3 |
| Absorption | |
| Active Site | ACT_SITE 469; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P14384 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA (By similarity). {ECO:0000250}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | FUNCTION: Cleaves substrates with C-terminal arginine residues. Modulates the Wnt signaling pathway, probably by cleaving some undefined protein. Regulates the development of skeletal elements during development, probably by activating WNT4. {ECO:0000269|PubMed:12944424}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (1); Metal binding (3); Signal peptide (1) |
| Keywords | Carboxypeptidase;Developmental protein;Disulfide bond;Extracellular matrix;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Wnt signaling pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 73,919 |
| Kinetics | |
| Metal Binding | METAL 245; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 248; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 377; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730 |
| Rhea ID | |
| Cross Reference Brenda |