| IED ID | IndEnz0002004882 |
| Enzyme Type ID | protease004882 |
| Protein Name |
Caspase-12 CASP-12 EC 3.4.22.- |
| Gene Name | Casp12 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MAAKRTHERDPIYKIKGLAKDMLDGVFDDLMDKNVLNGDELLKIGEGASLILSKAENLVESFFEKTEMAGKIFAGHIANSDKQLSLQFPSDDEEDELQKMFTPSSASESRGKVEDEEMEVNVGVAHASHLMLTVPQGIQSTEVQDSLKLCSRDWFCTMKTERAEEIYPVMEKEGRTRLALIICNKKFDYLFDRDDAETDILNMKELLQNLGYSVVIKENLTAQEMETELMKFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFTIFNNSNCPSLRNKPKILIMQACRGRHTGTIWVSTSKGIATADTDEECVLSHRWNNSITKAHVETDFIAFKSSTPHNISWKVGKSGSLFISKLIDCFKKYCWCYHLEEIFRKVQYSFEVPGELTQMPTIERVSMTRYFYLFPGN |
| Enzyme Length | 420 |
| Uniprot Accession Number | Q920D5 |
| Absorption | |
| Active Site | ACT_SITE 251; /evidence=ECO:0000250; ACT_SITE 299; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Modified residue (2); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Hydrolase;Phosphoprotein;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | O95786 |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 85; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 90; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10638761; 12598725; 14675152; 15855338; 16092975; 16139996; 16236330; 16574987; 16847061; 16979584; 17083921; 17433554; 17623297; 18273070; 18316105; 18332441; 18456407; 18477628; 18603371; 18675883; 18787714; 19215662; 19301230; 19406177; 19594550; 20818395; 23032698; 23934647; 24694971; 25331812; 25332219; 25547710; 25707520; 26238033; 26370333; 26801321; 26869403; 26884858; 27346262; 27781957; 28544790; 28825094; 29126976; 29428101; 29568958; 29659443; 30465396; 31007149; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,837 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.B66; |