| IED ID |
IndEnz0002004897 |
| Enzyme Type ID |
protease004897 |
| Protein Name |
Chagasin
|
| Gene Name |
cha |
| Organism |
Trypanosoma cruzi |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Discoba
Euglenozoa
Kinetoplastea (kinetoplasts)
Metakinetoplastina
Trypanosomatida
Trypanosomatidae
Trypanosoma
Schizotrypanum
Trypanosoma cruzi
|
| Enzyme Sequence |
MSHKVTKAHNGATLTVAVGELVEIQLPSNPTTGFAWYFEGGTKESPNESMFTVENKYFPPDSKLLGAGGTEHFHVTVKAAGTHAVNLTYMRPWTGPSHDSERFTVYLKAN |
| Enzyme Length |
110 |
| Uniprot Accession Number |
Q966X9 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Tight-binding and reversible inhibitor of papain-like cysteine proteases. {ECO:0000269|PubMed:11719560}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (10); Chain (1); Helix (2); Motif (1); Turn (4) |
| Keywords |
3D-structure;Cytoplasmic vesicle;Protease inhibitor;Thiol protease inhibitor |
| Interact With |
Q9NBD4 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Flagellar pocket {ECO:0000269|PubMed:11719560}. Cytoplasmic vesicle {ECO:0000269|PubMed:11719560}. Cell surface {ECO:0000269|PubMed:11719560}. Note=Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
NMR spectroscopy (1); X-ray crystallography (7) |
| Cross Reference PDB |
2FO8;
2H7W;
2NNR;
2NQD;
2OUL;
3CBJ;
3CBK;
3E1Z;
|
| Mapped Pubmed ID |
16490204;
17011790;
17502099;
17561110;
18515357;
19143838;
|
| Motif |
MOTIF 29..33; /note=NPTTG motif |
| Gene Encoded By |
|
| Mass |
12,040 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|