Detail Information for IndEnz0002004901
IED ID IndEnz0002004901
Enzyme Type ID protease004901
Protein Name Chymotrypsin-like elastase family member 3B
EC 3.4.21.70
Elastase IIIB
Elastase-3B
Protease E
Gene Name Cela3b Ela3 Ela3b
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MLRLLSSLLLVALASGCGQPSHNPSSRVVNGEEAVPHSWPWQVSLQYEKDGSFHHTCGGSLITPDWVLTAGHCISTSRTYQVVLGEHERGVEEGQEQVIPINAGDLFVHPKWNSMCVSCGNDIALVKLSRSAQLGDAVQLACLPPAGEILPNGAPCYISGWGRLSTNGPLPDKLQQALLPVVDYEHCSRWNWWGLSVKTTMVCAGGDIQSGCNGDSGGPLNCPADNGTWQVHGVTSFVSSLGCNTLRKPTVFTRVSAFIDWIEETIANN
Enzyme Length 269
Uniprot Accession Number Q9CQ52
Absorption
Active Site ACT_SITE 72; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 122; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.; EC=3.4.21.70;
DNA Binding
EC Number 3.4.21.70
Enzyme Function FUNCTION: Efficient protease with alanine specificity but only little elastolytic activity. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (4); Domain (1); Erroneous initiation (1); Propeptide (1); Sequence conflict (1); Signal peptide (1)
Keywords Disulfide bond;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 14610273; 15760467; 16518820; 18554416; 19585519; 21267068; 21677750; 22178591; 24793170; 28071719;
Motif
Gene Encoded By
Mass 28,905
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda