IED ID | IndEnz0002004901 |
Enzyme Type ID | protease004901 |
Protein Name |
Chymotrypsin-like elastase family member 3B EC 3.4.21.70 Elastase IIIB Elastase-3B Protease E |
Gene Name | Cela3b Ela3 Ela3b |
Organism | Mus musculus (Mouse) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
Enzyme Sequence | MLRLLSSLLLVALASGCGQPSHNPSSRVVNGEEAVPHSWPWQVSLQYEKDGSFHHTCGGSLITPDWVLTAGHCISTSRTYQVVLGEHERGVEEGQEQVIPINAGDLFVHPKWNSMCVSCGNDIALVKLSRSAQLGDAVQLACLPPAGEILPNGAPCYISGWGRLSTNGPLPDKLQQALLPVVDYEHCSRWNWWGLSVKTTMVCAGGDIQSGCNGDSGGPLNCPADNGTWQVHGVTSFVSSLGCNTLRKPTVFTRVSAFIDWIEETIANN |
Enzyme Length | 269 |
Uniprot Accession Number | Q9CQ52 |
Absorption | |
Active Site | ACT_SITE 72; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 122; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.; EC=3.4.21.70; |
DNA Binding | |
EC Number | 3.4.21.70 |
Enzyme Function | FUNCTION: Efficient protease with alanine specificity but only little elastolytic activity. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Disulfide bond (4); Domain (1); Erroneous initiation (1); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
Keywords | Disulfide bond;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen |
Interact With | |
Induction | |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 11217851; 12466851; 14610273; 15760467; 16518820; 18554416; 19585519; 21267068; 21677750; 22178591; 24793170; 28071719; |
Motif | |
Gene Encoded By | |
Mass | 28,905 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |