| IED ID |
IndEnz0002004903 |
| Enzyme Type ID |
protease004903 |
| Protein Name |
Cystatin cpi-1
|
| Gene Name |
cpi-1 Bm1_20105 |
| Organism |
Brugia malayi (Filarial nematode worm) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Spirurina
Spiruromorpha
Filarioidea
Onchocercidae
Brugia
Brugia malayi (Filarial nematode worm)
|
| Enzyme Sequence |
MFFPIVWLSVLLIISKSFAREIRLSRATYNEDDEEIQEVAEKAMEQVNDQTRYRNLYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKGAVGMNPMKCTIDSSKPTKQFKIEVWSAPWQNTFKVTLT |
| Enzyme Length |
127 |
| Uniprot Accession Number |
P90698 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Cysteine protease inhibitor which inhibits members of the peptidase C1 family (By similarity). Does not inhibit asparaginyl endopeptidase (PubMed:15664654). {ECO:0000250|UniProtKB:O16159, ECO:0000269|PubMed:15664654}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (1); Motif (1); Signal peptide (1) |
| Keywords |
Disulfide bond;Protease inhibitor;Reference proteome;Signal;Thiol protease inhibitor |
| Interact With |
|
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 68..72; /note=Secondary area of contact; /evidence=ECO:0000305 |
| Gene Encoded By |
|
| Mass |
14,612 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
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