| IED ID | IndEnz0002004910 |
| Enzyme Type ID | protease004910 |
| Protein Name |
Cystatin-1 Cystatin-I Fragment |
| Gene Name | |
| Organism | Capra hircus (Goat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Caprinae Capra Capra hircus (Goat) |
| Enzyme Sequence | DTHISEKIIDCNDIG |
| Enzyme Length | 15 |
| Uniprot Accession Number | P84911 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits papain, ficin and bromelain with an IC(50) of 0.09 uM, 0.115 uM and 0.113 uM respectively. Has antibacterial activity against Gram-positive bacteria S.aureus and S.hemolyticus, and against the Gram-negative bacterium E.coli. Reduced antibacterial activity against Gram-positive bacterium B.subtilis. No antibacterial activity against the Gram-negative bacterium P.fluorescens. {ECO:0000269|PubMed:16257555}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Non-terminal residue (1); Sequence uncertainty (1) |
| Keywords | Antibiotic;Antimicrobial;Direct protein sequencing;Glycoprotein;Protease inhibitor;Reference proteome;Thiol protease inhibitor |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000269|PubMed:16257555}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,673 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |