| IED ID | IndEnz0002004921 |
| Enzyme Type ID | protease004921 |
| Protein Name |
Ficolin-2 37 kDa elastin-binding protein Collagen/fibrinogen domain-containing protein 2 EBP-37 Ficolin-B Ficolin-beta Hucolin L-ficolin Serum lectin p35 |
| Gene Name | FCN2 FCNL |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPGPKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNIHALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNNQSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYNYSYKVSEMKVRPA |
| Enzyme Length | 313 |
| Uniprot Accession Number | Q15485 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:17215869}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (21); Chain (1); Compositional bias (1); Disulfide bond (3); Domain (2); Glycosylation (2); Helix (6); Metal binding (4); Modified residue (3); Natural variant (5); Region (2); Sequence conflict (3); Signal peptide (1); Turn (3) |
| Keywords | 3D-structure;Alternative splicing;Calcium;Collagen;Complement activation lectin pathway;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydroxylation;Immunity;Innate immunity;Lectin;Metal-binding;Reference proteome;Repeat;Secreted;Signal |
| Interact With | P17927; O75636; Q07954; P26022; P9WQP3; P9WQP1 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 77; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:8586615; MOD_RES 80; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:8586615; MOD_RES 86; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:8586615 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (13) |
| Cross Reference PDB | 2J0G; 2J0H; 2J0Y; 2J1G; 2J2P; 2J3F; 2J3G; 2J3O; 2J3U; 2J61; 4NYT; 4R9J; 4R9T; |
| Mapped Pubmed ID | 10925294; 12396008; 14280442; 14707097; 15078867; 15199963; 15804047; 17382393; 17581635; 17938215; 18596036; 20032467; 20375619; 20953506; 21054788; 25344472; 25447524; 6019133; 70787; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,001 |
| Kinetics | |
| Metal Binding | METAL 249; /note="Calcium"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J1G"; METAL 251; /note="Calcium"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J1G"; METAL 253; /note="Calcium; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J1G"; METAL 255; /note="Calcium; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J1G" |
| Rhea ID | |
| Cross Reference Brenda |