| IED ID | IndEnz0002004977 |
| Enzyme Type ID | protease004977 |
| Protein Name |
Endoplasmic reticulum metallopeptidase 1 EC 3.4.-.- FXNA-like protease |
| Gene Name | ermp1 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MESTVDGLTIRRPRYNVSAESASGYRREAGVREEKKPRQRDAGFGAAVPVLLLLYVLSVRGLVHISLRQLVTPGGHSTGFNASTAREYLQQITSIDSRTAGSPENEIIAVNYLLGKIKDIEEKINSVHRITVDVQRPTGTFSIDFLGGFTSYYDNITNIAVKLEPEHRAEHAVLANCHFDTVANTPGASDDAVSCAVMLEILGSLSSSSKPLKHAIIFLFNGAEENILQGSHGFITQHPWAKMVRAFINLEAAGVGGKELVFQTGPENPWLVQAYASAAVHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTWDRILTESIQRAGDNILGVLHYLATSSQLAESSQFRHGNMVFFDVCGLFVLSYPARLGTIINYITAAVTLFYISKKMIKYKQGGTNYVRDLVYGLIITLVSWVSALVTVLIIAVLVSLAGKALSWYTHFYVSIFLYGSAAVAKFILVHSLAKTYFFAGASSQYLGDLFFDISLITWCIPLVLLTQSGLCSAYFFAAWIIFPLLTKLLLQPDIIHQGSPYKFTAVYLLGLFPPYLHTMYHVWAVFEMFTPILGRSGTEIPPDIVLGFLIIACTIILITYFISFIYLLKSTKKIIVTLAVLSVLTLLLVCSGMFFPYSSSNDSPKPKRIFLQHTTRTFHSLTGEVVKRDSGIWINGFDYTGISYVTPHIPELNETVRAPCDDAPLCGFPWYFPVHHLIRKNWYLPAPPAPINEHTDFKLVSREEMSWGATRLFFEVKGPSHMTVYVRPNTNTVLSSWSLGDGIPVASGETDYFIFYSHGLYAPAWKFWIELKNSAKESKGIVTVAVGSHYFFGDSRNSPDLETLELKFPDWSFPSSWVCTYDLYEY |
| Enzyme Length | 876 |
| Uniprot Accession Number | Q0VGW4 |
| Absorption | |
| Active Site | ACT_SITE 224; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (1); Glycosylation (3); Metal binding (6); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6UPR8}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 97,793 |
| Kinetics | |
| Metal Binding | METAL 178; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 190; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 190; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 225; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 251; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 327; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |