| IED ID | IndEnz0002004983 |
| Enzyme Type ID | protease004983 |
| Protein Name |
CAAX prenyl protease 2 EC 3.4.-.- Farnesylated proteins-converting enzyme 2 AtFACE-2 Prenyl protein-specific endoprotease 2 Protein RAS-CONVERTING ENZYME 1 AtRCE1 |
| Gene Name | FACE2 RCE1 At2g36305 F2H17 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MATDGESISMSLAVATCVAMALFYVLILYVPTVILRLPSASSYTEFMIRRFICAAICTVASLVFTAFILPIKSWEASYILGVYGIRKDHLWQGVVYPLLLTSLVYAGSLVLKLFTLLESWKENGGGCSSFNYIRSFFQTIPASVLTSASNVSVWRNFIVAPVTEELVFRSCMIPLLLCAGFRINTAIFLCPVLFSLAHLNHFREMYIRHNRSYLRASLIVGLQLGYTVIFGAYASFLFIRTGHLAAPLFAHIFCNYMGLPVLYANGKGLVSAAFLGGVVGFVLLLFPLTKPLMYNDSTNDCPCWLGYCLWN |
| Enzyme Length | 311 |
| Uniprot Accession Number | Q8GW19 |
| Absorption | |
| Active Site | ACT_SITE 164; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:Q6LZY8; ACT_SITE 198; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:Q6LZY8 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK) and N-ethylmaleimide, but not by EDTA. {ECO:0000269|PubMed:12928436}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. The substrate specificity is only partially overlapping with that of FACE1. {ECO:0000269|PubMed:12928436, ECO:0000269|PubMed:18641086}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Sequence conflict (2); Site (2); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18641086}; Multi-pass membrane protein {ECO:0000269|PubMed:18641086}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18957507; 23940253; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,548 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |