| IED ID | IndEnz0002005025 |
| Enzyme Type ID | protease005025 |
| Protein Name |
Integrin alpha-E Integrin alpha M290 CD antigen CD103 Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain |
| Gene Name | Itgae |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MKWLFHTLLCMASLKPQGAFNLDVDWAWVTALQPGAPAVLSSLLHQDPSNNQTCLLVARRSSNRNTAALYRCAISISPDEIACQPVEHICMPKGRYQGVTLVGNHNGVLVCIQVQARKFRSLNSELTGACSLLTPNLDLQAQAYFSDLEGFLDPGAHVDSGDYCRSKGGSTGEEKKSARRRRTVEEEDEEEDGTEIAIVLDGSGSIEPSDFQKAKNFISTMMRNFYEKCFECNFALVQYGAVIQTEFDLQESRDINASLAKVQSIVQVKEVTKTASAMQHVLDNIFIPSRGSRKKALKVMVVLTDGDIFGDPLNLTTVINSPKMQGVVRFAIGVGDAFKNNNTYRELKLIASDPKEAHTFKVTNYSALDGLLSKLQQHIVHMEGTVGDALQYQLAQTGFSAQILDKGQVLLGTVGAFNWSGGALLYSTQNGRGCFLNQTAKEDSRTVQYSYLGYSLAVLHKAHGVSYVAGAPRHKLRGAVFELRKEDREEDAFVRRIEGEQMGSYFGSVLCPVDIDMDGTTDFLLVAAPFYHIRGEEGRVYVYQVPEQDASFSLAHTLSGHPGLTNSRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLYDSPSQQIRASSVASGLHYFGMSVSGGLDFNGDGLADITVGSRDSAVVLRSRPVVDLTVSMTFTPDALPMVFIGKMDVKLCFEVDSSGVASEPGLREMFLNFTVDVDVTKQRQRLQCEDSSGCQSCLRKWNGGSFLCEHFWLISTEELCEEDCFSNITIKVTYEFQTSGGRRDYPNPTLDHYKEPSAIFQLPYEKDCKNKVFCIAEIQLTTNISQQELVVGVTKEVTMNISLTNSGEDSYMTNMALNYPRNLQFKKIQKPVSPDVQCDDPKPVASVLVMNCKIGHPILKRSSVNVSVTWQLEESVFPNRTADITVTISNSNEKSLARETRSLQFRHAFIAVLSRPSVMYMNTSQSPSDHKEFFFNVHGENLFGAVFQLQICVPIKLQDFQIVRVKNLTKTQDHTECTQSQEPACGSDPVQHVKEWHSVVCAITSNKENVTVAAEISVGHTKQLLRDVSELPILGEISFNKSLYEGLNAENHRTKITVIFLKEEETRSLPLIIGSSIGGLLVLVVIIAILFKCGFFKRKYQQLNLESTRRAQLKADSLLQD |
| Enzyme Length | 1167 |
| Uniprot Accession Number | Q60677 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 514..522; /evidence=ECO:0000255; CA_BIND 578..586; /evidence=ECO:0000255; CA_BIND 646..654; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Calcium binding (3); Chain (3); Compositional bias (1); Disulfide bond (7); Domain (1); Glycosylation (17); Motif (1); Region (2); Repeat (7); Sequence conflict (8); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Calcium;Cell adhesion;Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10352281; 10898487; 11086102; 11311556; 11696590; 11934870; 12164945; 12242333; 12370250; 12466851; 12904471; 14610273; 14688336; 14688352; 15187103; 15681774; 15845457; 16141072; 16216886; 16227984; 16455972; 16565389; 16585587; 16723705; 16769892; 16869802; 17429444; 17513734; 17620361; 18250468; 18292524; 18492951; 18562709; 18710932; 18799693; 19008373; 19162441; 19553521; 19645708; 19893044; 20008524; 20008528; 20038600; 20039445; 20421390; 20565292; 21267068; 21345961; 21525388; 21562159; 21573179; 21587207; 21660938; 21677750; 21779359; 22012243; 22068168; 22268142; 22327568; 22422267; 22504644; 22664873; 22687584; 23034280; 23395676; 23632327; 23733880; 24162776; 24194600; 24670804; 25312824; 25322675; 25525188; 25527788; 25681437; 25706747; 26104914; 26169940; 26174764; 26203637; 26416905; 26526996; 26878989; 27379516; 27543429; 27626380; 27760760; 27820700; 27861803; 27869233; 28108233; 28423181; 28628641; 29374077; 29543979; 30598548; 30700910; 30865878; 31570722; 32433498; 32439709; 32667911; 33268774; 33359357; 33584680; 34129058; 34253059; 9685670; |
| Motif | MOTIF 1140..1144; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 128,906 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |