| IED ID | IndEnz0002005027 |
| Enzyme Type ID | protease005027 |
| Protein Name |
Integrin alpha-L CD11 antigen-like family member A Leukocyte adhesion glycoprotein LFA-1 alpha chain LFA-1A Leukocyte function-associated molecule 1 alpha chain CD antigen CD11a |
| Gene Name | ITGAL CD11A |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD |
| Enzyme Length | 1170 |
| Uniprot Accession Number | P20701 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 468..476; /evidence=ECO:0000255; CA_BIND 530..538; /evidence=ECO:0000255; CA_BIND 590..598; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Beta strand (40); Calcium binding (3); Chain (1); Compositional bias (1); Disulfide bond (7); Domain (1); Glycosylation (12); Helix (22); Modified residue (1); Motif (1); Mutagenesis (1); Natural variant (4); Region (1); Repeat (7); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (8) |
| Keywords | 3D-structure;Alternative splicing;Calcium;Cell adhesion;Cell membrane;Direct protein sequencing;Disulfide bond;Glycoprotein;Host-virus interaction;Integrin;Magnesium;Membrane;Metal-binding;Phagocytosis;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | P05362; P08575; Q9WMX2 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16301335}; Single-pass type I membrane protein {ECO:0000255}. |
| Modified Residue | MOD_RES 1165; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:16301335 |
| Post Translational Modification | PTM: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents. {ECO:0000269|PubMed:16301335}. |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | NMR spectroscopy (3); X-ray crystallography (38) |
| Cross Reference PDB | 1CQP; 1DGQ; 1LFA; 1MJN; 1MQ8; 1MQ9; 1MQA; 1RD4; 1T0P; 1XDD; 1XDG; 1XUO; 1ZON; 1ZOO; 1ZOP; 2ICA; 2K8O; 2M3E; 2O7N; 3BN3; 3BQM; 3BQN; 3E2M; 3EOA; 3EOB; 3F74; 3F78; 3HI6; 3M6F; 3TCX; 4IXD; 5E6R; 5E6S; 5E6U; 6BXB; 6BXF; 6BXJ; 6CKB; 7KC3; 7KC5; 7KC6; |
| Mapped Pubmed ID | 10653701; 11792712; 11857637; 11867690; 11929876; 11953106; 12020947; 12036881; 12117984; 12139949; 12163056; 12163503; 12202941; 12207338; 12368450; 12516552; 12616499; 12694184; 12815062; 12845325; 12847234; 12855590; 14676297; 14688105; 14695458; 14722085; 14992576; 15113754; 15208262; 15304496; 15308572; 15611342; 15622747; 15681301; 15686945; 15693793; 15728350; 15730520; 15834409; 15851656; 15946252; 15958383; 15983060; 16002691; 16037628; 16038038; 16100282; 16164020; 16207819; 16249234; 16472601; 16492228; 16505487; 16622014; 16705652; 16855029; 16920795; 16963559; 17038526; 17045822; 17078873; 17125246; 17291752; 17353931; 17430469; 17468108; 17486117; 17525755; 17591777; 17673459; 17785425; 17913807; 18079697; 18156711; 18195072; 18199751; 18339898; 18691975; 18778938; 18783948; 18922916; 18985028; 19029120; 19050286; 19073598; 19135988; 19258452; 19332643; 19502238; 19805116; 19913121; 20338181; 20403997; 20405922; 20445017; 20511548; 20516718; 20574620; 20628086; 20681010; 20953905; 21150319; 21152086; 21192791; 21206905; 21270395; 21454358; 21540444; 21541792; 21576384; 21597477; 21669874; 21705617; 22190034; 22384114; 22411821; 22467872; 23160181; 23188505; 23398146; 23418509; 23450818; 23514737; 23650620; 23726040; 23981064; 24006483; 24238281; 24258149; 24276331; 24829201; 24982892; 25147050; 25155097; 25231265; 25378583; 25678252; 25684021; 26884833; 26936951; 28430662; 28699640; 29229906; 30018079; 30209215; 30237316; 30329215; 33160625; 8995416; |
| Motif | MOTIF 1115..1119; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 128,770 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |